ID   CARP_SACFI              Reviewed;         390 AA.
AC   P22929;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Acid protease;
DE            EC=3.4.23.-;
DE   Flags: Precursor;
GN   Name=PEP1;
OS   Saccharomycopsis fibuligera (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycopsidaceae; Saccharomycopsis.
OX   NCBI_TaxID=4944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hirata D., Fukui S., Yamashita I.;
RT   "Nucleotide sequence of the secretable acid protease gene PEPI in the yeast
RT   Saccharomycopsis fibuligera.";
RL   Agric. Biol. Chem. 52:2647-2649(1988).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR   EMBL; D00313; BAA00215.1; -; Genomic_DNA.
DR   PIR; JT0334; JT0334.
DR   AlphaFoldDB; P22929; -.
DR   SMR; P22929; -.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05474; SAP_like; 1.
DR   Gene3D; 2.40.70.10; -; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR033876; SAP-like.
DR   PANTHER; PTHR47965; PTHR47965; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease; Hydrolase; Protease; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..390
FT                   /note="Acid protease"
FT                   /id="PRO_0000025847"
FT   DOMAIN          75..386
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT   ACT_SITE        93
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT   ACT_SITE        282
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
SQ   SEQUENCE   390 AA;  41263 MW;  350BF97116C54796 CRC64;
     MLFSKSLLLS VLASLSFAAP VEKREKTLTL DFDVKRISSK AKNVTVASSP GFRRNLRAAS
     DAGVTISLEN EYSFYLTTIE IGTPGQKLQV DVDTGSSDLW VPGQGTSSLY GTYDHTKSTS
     YKKDRSGFSI SYGDGSSARG DWAQETVSIG GASITGLEFG DATSQDVGQG LLGIGLKGNE
     ASAQSSNSFT YDNLPLKLKD QGLIDKAAYS LYLNSEDATS GSILFGGSDS SKYSGSLATL
     DLVNIDDEGD STSGAVAFFV ELEGIEAGSS SITKTTYPAL LDSGTTLIYA PSSIASSIGR
     EYGTYSYSYG GYVTSCDATG PDFKFSFNGK TITVPFSNLL FQNSEGDSEC LVGVLSSGSN
     YYILGDAFLR SAYVYYDIDN SQVGIAQAKY