ID   Y4041_METAC             Reviewed;         349 AA.
AC   Q8TIV0;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UPF0219 protein MA_4041 {ECO:0000255|HAMAP-Rule:MF_01409};
GN   OrderedLocusNames=MA_4041;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. UPF0219 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01409}.
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DR   EMBL; AE010299; AAM07389.1; -; Genomic_DNA.
DR   RefSeq; WP_011023934.1; NC_003552.1.
DR   AlphaFoldDB; Q8TIV0; -.
DR   SMR; Q8TIV0; -.
DR   STRING; 188937.MA_4041; -.
DR   EnsemblBacteria; AAM07389; AAM07389; MA_4041.
DR   GeneID; 1475935; -.
DR   KEGG; mac:MA_4041; -.
DR   HOGENOM; CLU_039592_7_0_2; -.
DR   InParanoid; Q8TIV0; -.
DR   OMA; YAKHKGK; -.
DR   OrthoDB; 12601at2157; -.
DR   PhylomeDB; Q8TIV0; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IBA:GO_Central.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IBA:GO_Central.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 1.
DR   HAMAP; MF_01409; UPF0219; 1.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004656; FabH-rel.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR00748; HMG_CoA_syn_Arc; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..349
FT                   /note="UPF0219 protein MA_4041"
FT                   /id="PRO_0000057613"
SQ   SEQUENCE   349 AA;  37131 MW;  A5A132253BA55A1D CRC64;
     MTIGIVSYGA YVPRYRIKIE EIARLWGDDA EALKNGLMVY EKSVPDVDED AATIAVEAAR
     YAMARSGVDP SRIGAVYTGS ESHPYAVKPT STIVAQAIGA TPEMTAADFE FACKAGTAAV
     QACMGLVGSG MIDLGLAIGA DVSQGAPSDA LEYTAAAGGV ACLIGRKESE LAAIIEDTYS
     FTTDTPDFWR REGMPYPEHG GRFTGEPGYF KHVTNGAKGL LEKLGTKPED YDYAVFHQPN
     GKFPSKAAKI LGFTKAQITP GLVVPKIGNT YSGSCLMGIA ATLDQAKPGD RIFATAFGSG
     AGSDAFSITV TDRIEEIRNR APKVSELIKD PVYIDYARYA RHKGKIRLA