ID   CARR_PECCC              Reviewed;         244 AA.
AC   Q46751;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Transcriptional activator protein CarR;
GN   Name=carR;
OS   Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp.
OS   carotovora).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 39048 / GS101 / SC 12;
RX   PubMed=7711893; DOI=10.1099/13500872-141-3-541;
RA   McGowan S.J., Sebaihia M., Jones S., Yu B., Bainton N., Chan P.F.,
RA   Bycroft B., Stewart G.S.A.B., Williams P., Salmond G.P.C.;
RT   "Carbapenem antibiotic production in Erwinia carotovora is regulated by
RT   CarR, a homologue of the LuxR transcriptional activator.";
RL   Microbiology 141:541-550(1995).
CC   -!- FUNCTION: Functions as an OHLL responsive transcriptional regulator
CC       which acts in the control of the biosynthesis of carbapenem
CC       antibiotics.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
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DR   EMBL; U17224; AAC45995.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q46751; -.
DR   SMR; Q46751; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Antibiotic biosynthesis; DNA-binding; Quorum sensing;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Transcriptional activator protein CarR"
FT                   /id="PRO_0000184142"
FT   DOMAIN          162..227
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        186..205
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   244 AA;  28137 MW;  F908C1E975BF3277 CRC64;
     MDHEIHSFIK RKLKGVGDVW FSYFMMSKNS TSQPYIISNY PEAWMKEYIK KEMFLSDPII
     VASLARITPF SWDDNDIVTL RAKNQDVFIS SVQHDISSGY TFVLHDHDNN VATLSIANHL
     EDANFEKCMK NHENDLQMLL VNVHEKVMAY QRAINDQDNP PDNSRNALLS PRETEVLFLV
     SSGRTYKEVS RILGISEVTV KFHINNSVRK LDVINSRHAI TKALELNLFH SPCEPVVMKH
     MDAR