ID   CARR_PSEAE              Reviewed;         223 AA.
AC   Q9I0I1;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Response regulator protein CarR {ECO:0000303|PubMed:26755627};
GN   Name=carR; OrderedLocusNames=PA2657;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION.
RX   PubMed=26755627; DOI=10.1128/jb.00963-15;
RA   Guragain M., King M.M., Williamson K.S., Perez-Osorio A.C., Akiyama T.,
RA   Khanam S., Patrauchan M.A., Franklin M.J.;
RT   "The Pseudomonas aeruginosa PAO1 Two-Component Regulator CarSR Regulates
RT   Calcium Homeostasis and Calcium-Induced Virulence Factor Production through
RT   Its Regulatory Targets CarO and CarP.";
RL   J. Bacteriol. 198:951-963(2016).
CC   -!- FUNCTION: Member of the two-component regulatory system CarS/CarR that
CC       regulates the expression of multiple genes involved in calcium
CC       signaling and homeostasis including CarO and CarP (PubMed:26755627).
CC       May function as a transcriptional activator by direct binding to a cis-
CC       acting sequence upstream of the target gene promoters (Probable).
CC       {ECO:0000269|PubMed:26755627, ECO:0000305|PubMed:26755627}.
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DR   EMBL; AE004091; AAG06045.1; -; Genomic_DNA.
DR   PIR; D83314; D83314.
DR   RefSeq; NP_251347.1; NC_002516.2.
DR   RefSeq; WP_003090494.1; NZ_QZGE01000008.1.
DR   AlphaFoldDB; Q9I0I1; -.
DR   SMR; Q9I0I1; -.
DR   STRING; 287.DR97_5304; -.
DR   PaxDb; Q9I0I1; -.
DR   PRIDE; Q9I0I1; -.
DR   DNASU; 882366; -.
DR   EnsemblBacteria; AAG06045; AAG06045; PA2657.
DR   GeneID; 882366; -.
DR   KEGG; pae:PA2657; -.
DR   PATRIC; fig|208964.12.peg.2780; -.
DR   PseudoCAP; PA2657; -.
DR   HOGENOM; CLU_000445_30_1_6; -.
DR   InParanoid; Q9I0I1; -.
DR   OMA; VWGYDAY; -.
DR   PhylomeDB; Q9I0I1; -.
DR   BioCyc; PAER208964:G1FZ6-2697-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..223
FT                   /note="Response regulator protein CarR"
FT                   /id="PRO_0000449416"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        125..219
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   223 AA;  24729 MW;  748DC6B93735C9E7 CRC64;
     MRLLLVEDHV PLADELMASL TRQGYAVDWL ADGRDAAVQG ASEPYDLIIL DLGLPGRPGL
     EILQEWRGLG LATPVLILTA RGSWAERIDG LKAGADDYLT KPFHPEELAL RIQALLRRAH
     GLANQSQLEA AGLRLDEQRQ CVCLNGADVD LTAAEFRLLR YFMLHPGQVL SKGHLAEHLY
     DGETERDSNV IEVHVNHLRR KLGREVIETR RGQGYRYAGV AAG