ID   CARS_MYXXA              Reviewed;         111 AA.
AC   Q06911;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Antirepressor protein CarS;
GN   Name=carS;
OS   Myxococcus xanthus.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=34;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=DK101;
RX   PubMed=7934835; DOI=10.1111/j.1365-2958.1993.tb00943.x;
RA   McGowan S.J., Gorham H.C., Hodgson D.A.;
RT   "Light-induced carotenogenesis in Myxococcus xanthus: DNA sequence analysis
RT   of the carR region.";
RL   Mol. Microbiol. 10:713-735(1993).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INTERACTION WITH CARA.
RC   STRAIN=DK1050;
RX   PubMed=11748235; DOI=10.1074/jbc.m110351200;
RA   Lopez-Rubio J.J., Elias-Arnanz M., Padmanabhan S., Murillo F.J.;
RT   "A repressor-antirepressor pair links two loci controlling light-induced
RT   carotenogenesis in Myxococcus xanthus.";
RL   J. Biol. Chem. 277:7262-7270(2002).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH CARH.
RC   STRAIN=DK1050;
RX   PubMed=18315685; DOI=10.1111/j.1365-2958.2007.06086.x;
RA   Perez-Marin M.C., Padmanabhan S., Polanco M.C., Murillo F.J.,
RA   Elias-Arnanz M.;
RT   "Vitamin B12 partners the CarH repressor to downregulate a photoinducible
RT   promoter in Myxococcus xanthus.";
RL   Mol. Microbiol. 67:804-819(2008).
CC   -!- FUNCTION: Involved in carotenoid biosynthesis. Antagonizes the
CC       transcriptional repressor proteins CarA and CarH by preventing their
CC       binding to DNA. Can also dissociate preformed CarA-DNA complexes. Does
CC       not bind DNA. {ECO:0000269|PubMed:11748235,
CC       ECO:0000269|PubMed:18315685}.
CC   -!- SUBUNIT: Monomer. Interacts with CarA and CarH.
CC       {ECO:0000269|PubMed:11748235, ECO:0000269|PubMed:18315685}.
CC   -!- INDUCTION: By light. {ECO:0000269|PubMed:7934835}.
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DR   EMBL; X71062; CAA50383.1; -; Genomic_DNA.
DR   PIR; S39879; S39879.
DR   RefSeq; WP_011554097.1; NZ_JABFNQ010000003.1.
DR   PDB; 2KSS; NMR; -; A=1-86.
DR   PDBsum; 2KSS; -.
DR   AlphaFoldDB; Q06911; -.
DR   BMRB; Q06911; -.
DR   SMR; Q06911; -.
DR   GeneID; 41361419; -.
DR   OMA; APEWARN; -.
DR   EvolutionaryTrace; Q06911; -.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd12840; CarS; 1.
DR   InterPro; IPR033807; CarS_antirepressor.
DR   InterPro; IPR041199; CarS_SH3.
DR   Pfam; PF18354; SH3_18; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Carotenoid biosynthesis; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..111
FT                   /note="Antirepressor protein CarS"
FT                   /id="PRO_0000089321"
FT   STRAND          23..25
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   STRAND          31..33
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   TURN            37..41
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   STRAND          43..48
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   STRAND          58..63
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   STRAND          65..68
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   STRAND          73..75
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   TURN            78..80
FT                   /evidence="ECO:0007829|PDB:2KSS"
FT   STRAND          81..83
FT                   /evidence="ECO:0007829|PDB:2KSS"
SQ   SEQUENCE   111 AA;  12210 MW;  D7E57DA5C2E9BD8E CRC64;
     MIQDPSLIIC HDVDGAPVRI GAKVKVVPHS EDGTISQRFL GQTGIVVGLV FDDPATQYPD
     DPLIQVLVEG LGEDLFFPEE LELAPEWARN RIAQHRQAVR TGGRSSLERL P