ID   CARTF_BOVIN             Reviewed;         703 AA.
AC   Q58CW6;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Calcium-responsive transcription factor;
DE   AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein;
GN   Name=CARF; Synonyms=ALS2CR8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Acts as a transcriptional activator that mediates the
CC       calcium- and neuron-selective induction of BDNF exon III transcription.
CC       Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3'
CC       sequence (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The N-terminus is necessary for DNA-binding. The C-terminus is
CC       necessary for transcriptional activation (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; BT021831; AAX46678.1; -; mRNA.
DR   RefSeq; NP_001027465.1; NM_001032294.1.
DR   AlphaFoldDB; Q58CW6; -.
DR   SMR; Q58CW6; -.
DR   STRING; 9913.ENSBTAP00000021288; -.
DR   PaxDb; Q58CW6; -.
DR   PRIDE; Q58CW6; -.
DR   GeneID; 509072; -.
DR   KEGG; bta:509072; -.
DR   CTD; 79800; -.
DR   eggNOG; ENOG502QWYS; Eukaryota.
DR   InParanoid; Q58CW6; -.
DR   OrthoDB; 366551at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR   GO; GO:0035865; P:cellular response to potassium ion; ISS:UniProtKB.
DR   GO; GO:0061400; P:positive regulation of transcription from RNA polymerase II promoter in response to calcium ion; ISS:UniProtKB.
DR   InterPro; IPR029309; CaRF.
DR   PANTHER; PTHR14694; PTHR14694; 1.
DR   Pfam; PF15299; ALS2CR8; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..703
FT                   /note="Calcium-responsive transcription factor"
FT                   /id="PRO_0000076171"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  78135 MW;  B577AB18F36123CA CRC64;
     MEQSVDSLKV NHNDSEESKT DSQHLTYMDS SEPSFGQDGS PRVLPVTTPE EDGSLTSQNI
     PGPLTQAQIL SAEQFHLVDQ NGQPVQYELQ SLGDSNAQMM IVASPSENGQ VLRVIPSPQT
     GMTQVIIPQG PLVDENSPQD VSEEKPSDRN LPAVRVDALA DSNSSYVLHP QASLTLPKKT
     VTRILEEPLL APLQPLSSNT PIWACRLRSC EKIGDSYRGY CVSETELESV LTFHKQQTQS
     VWGTRQSPSP AKPATRLMWK SQYVPYDGIP FVNAGSRAVV MECQYGPRRK GFQLKKIGEL
     ENRSCQLYKA TCPARIYIKK VQKFPDYRVP TDPKIDRKII RMEQEKAFNL LKKNLVDAGG
     VLRWYVQLPT QQAHQYHELE TPCLPLSSSS FPISSLEEEE AAIRDENCTL PSRLHPQVAH
     KIQELVSQGI EQVYAVRKQL RKFVERELFK PDEVPERHNL SFFPTVNDIR NHIHEVQKSL
     RNGDNICNSE IIPATLQWTT DSGNILRETV TVTLAEGNSQ GESVSSKLET NQTRNSLSPE
     PAQLLSSLSS FQPKIFTHLQ GLQLQPRFTS DGSPALISVN NHPSSSPSRL LDSVRSVVMN
     NNSLLLGQTH CLQTDTPLTP NSSISSTMSN LPGPDQNLVA VDQLVEVEDV EDTETLEGNV
     HRILLGNVQT IPIQIIDNPP VLSNFGSILK EPIFDCFGGP IKI