CARTF_RAT
ID CARTF_RAT Reviewed; 587 AA.
AC D4A7U2;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Calcium-responsive transcription factor;
DE AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein;
DE AltName: Full=Calcium-response factor;
DE Short=CaRF;
GN Name=Carf; Synonyms=Als2cr8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, DNA-BINDING, AND SUBCELLULAR LOCATION.
RX PubMed=11832226; DOI=10.1016/s0896-6273(01)00561-x;
RA Tao X., West A.E., Chen W.G., Corfas G., Greenberg M.E.;
RT "A calcium-responsive transcription factor, CaRF, that regulates neuronal
RT activity-dependent expression of BDNF.";
RL Neuron 33:383-395(2002).
CC -!- FUNCTION: Acts as a transcriptional activator that mediates the
CC calcium- and neuron-selective induction of BDNF exon III transcription.
CC Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3'
CC sequence. {ECO:0000269|PubMed:11832226}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11832226}.
CC -!- DOMAIN: The N-terminus is necessary for DNA-binding. The C-terminus is
CC necessary for transcriptional activation (By similarity).
CC {ECO:0000250}.
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DR EMBL; AABR06060608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473965; EDL98937.1; -; Genomic_DNA.
DR RefSeq; NP_001100385.1; NM_001106915.1.
DR AlphaFoldDB; D4A7U2; -.
DR SMR; D4A7U2; -.
DR STRING; 10116.ENSRNOP00000023536; -.
DR PaxDb; D4A7U2; -.
DR Ensembl; ENSRNOT00000023536; ENSRNOP00000023536; ENSRNOG00000017491.
DR GeneID; 301446; -.
DR KEGG; rno:301446; -.
DR UCSC; RGD:1306822; rat.
DR CTD; 79800; -.
DR RGD; 1306822; Carf.
DR eggNOG; ENOG502QWYS; Eukaryota.
DR GeneTree; ENSGT00390000013916; -.
DR HOGENOM; CLU_023513_0_0_1; -.
DR InParanoid; D4A7U2; -.
DR OrthoDB; 366551at2759; -.
DR PhylomeDB; D4A7U2; -.
DR PRO; PR:D4A7U2; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Proteomes; UP000234681; Chromosome 9.
DR Bgee; ENSRNOG00000017491; Expressed in testis and 19 other tissues.
DR ExpressionAtlas; D4A7U2; baseline and differential.
DR GO; GO:0001652; C:granular component; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR GO; GO:0035865; P:cellular response to potassium ion; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0061400; P:positive regulation of transcription from RNA polymerase II promoter in response to calcium ion; IDA:UniProtKB.
DR GO; GO:0051090; P:regulation of DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR029309; CaRF.
DR PANTHER; PTHR14694; PTHR14694; 1.
DR Pfam; PF15299; ALS2CR8; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..587
FT /note="Calcium-responsive transcription factor"
FT /id="PRO_0000423350"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 64667 MW; 9D27A46E0563E411 CRC64;
MLASSQMTSV SEEKPIGGSL PAVSTDALED SASSYSLHSQ ASLVGPRKSG TRTLEEPLLA
PLQPLSCNTP MWACRLRSCE KIGDSYRGYC VSETELESVL TFHKQQTQTV WGTRQSPSPA
KPATRLMWKS QYVPYDGIPF VNAGSRAVVM ECQYGPRRKG FQLKKISEQE SRSCHLYKAT
CPARIYIKKV QKFPDYRVPT DPQIDRKTIR MEQEKAFTML KKNLVDAGGV LRWYVQLPTQ
QAHQYHEPET PGVPLSPSPF PMSPLEEEEA IIRDENCVLP SRLHPQVAHK IQELVSQGVG
QVYAVRKQLR KFVERELFKP DEVPERHNLS FFPTVNDIKN HIHEVQKSLQ TGDVVYNSEI
IPATLQWTTD SGNILRETVT VTFAEGNLLK EPITSKMGTS QTQTSLSPEP LPLLSPLSSF
QPKIFTHLQA LKLQPRLSSP DGSQALVSVN SHPSSSPPGL DTAGNAEANN HSLLLGQSQN
LGTDTCLPEN SSTASPMGSL PESVQNLVAV DQLVGGEDAE DAGNLEGNVK RTLLGDAHTI
PIHILDSHPA LVEEDTLSMN QVKQEPNEPT LSTEAKTLLD CKNVSAT
