ID   Y4116_ARATH             Reviewed;         527 AA.
AC   O04615; F4JHY9;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=BTB/POZ domain-containing protein At4g01160;
GN   OrderedLocusNames=At4g01160; ORFNames=A_IG002N01.11, F2N1.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEE81989.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF007269; AAB61041.1; -; Genomic_DNA.
DR   EMBL; AL161491; CAB80925.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE81989.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; ANM66602.1; -; Genomic_DNA.
DR   PIR; T01725; T01725.
DR   RefSeq; NP_001328487.1; NM_001340303.1.
DR   RefSeq; NP_192025.2; NM_116346.3.
DR   AlphaFoldDB; O04615; -.
DR   SMR; O04615; -.
DR   PaxDb; O04615; -.
DR   PRIDE; O04615; -.
DR   EnsemblPlants; AT4G01160.2; AT4G01160.2; AT4G01160.
DR   GeneID; 828156; -.
DR   Gramene; AT4G01160.2; AT4G01160.2; AT4G01160.
DR   KEGG; ath:AT4G01160; -.
DR   Araport; AT4G01160; -.
DR   eggNOG; ENOG502QT6M; Eukaryota.
DR   HOGENOM; CLU_024600_2_0_1; -.
DR   InParanoid; O04615; -.
DR   OrthoDB; 462254at2759; -.
DR   PhylomeDB; O04615; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:O04615; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O04615; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0010114; P:response to red light; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR045890; POB1-like.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46336; PTHR46336; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..527
FT                   /note="BTB/POZ domain-containing protein At4g01160"
FT                   /id="PRO_0000406782"
FT   DOMAIN          111..180
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          233..327
FT                   /note="BACK"
SQ   SEQUENCE   527 AA;  59237 MW;  F9A5CB6ECA9B8046 CRC64;
     MDLSLSGGDF RFAFNNVNFS DRLLRIEITQ SSGEGEVICS SIVDWARDRK RRREDVTNHT
     NDATCHVESD LNKNSCEIVN ENSNNKTQVL VTAAEQEPKS GGEDENERLT NNNTSVLSVQ
     ELHISSAILA AKSPFFYKLF SNGMLESEQK QMTLKIDASE ETAVMELLKF MYSNSLSVTA
     SSALLDVLMV ADKFEVASCM KYCSQLLLKM PMTLESSLLL LDLPSSLLMA DSVKPLTNAA
     RQFIASRYKN MSKITMEELM ALPLVGIEAI LASDGLEIQS EDVVYEVVLK WVKSHYSVLE
     ARQEVLGSHL ARYIRFPHMT TDRLKKILTS NDFRPSVASK LVVEALFFKT ESLAHQHVLL
     AHEQPASTSR RFAKRAYVHR PIKIVEFAVP RPQCIIYLDL KRKECESIYP SSRISSQQFT
     LGGQGFFLSA QCNMDHLCLI HCFGLFIGMQ ENGSASASVT VDYDFSVRSK PTMEFVGKFK
     GIYTFTRGKA VGCRNLLGIP WDIFTAKNCP YFINDVLHLR ADLSIRL