Y4117_ARATH
ID Y4117_ARATH Reviewed; 1095 AA.
AC O82500; Q9T016;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=Putative disease resistance protein At4g11170;
DE EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};
GN OrderedLocusNames=At4g11170; ORFNames=F2P3.8, T22B4.150;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC -!- DOMAIN: The TIR domain mediates NAD(+) hydrolase (NADase) activity.
CC Self-association of TIR domains is required for NADase activity.
CC {ECO:0000255|PROSITE-ProRule:PRU00204}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB43052.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g11170 has been split into 2 genes: At4g11170 and At4g11175.; Evidence={ECO:0000305};
CC Sequence=CAB81218.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g11170 has been split into 2 genes: At4g11170 and At4g11175.; Evidence={ECO:0000305};
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DR EMBL; AF080120; AAC35544.1; -; Genomic_DNA.
DR EMBL; AL049876; CAB43052.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161531; CAB81218.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82980.1; -; Genomic_DNA.
DR PIR; T01916; T01916.
DR PIR; T08196; T08196.
DR RefSeq; NP_192855.1; NM_117187.2.
DR AlphaFoldDB; O82500; -.
DR SMR; O82500; -.
DR STRING; 3702.AT4G11170.1; -.
DR PaxDb; O82500; -.
DR PRIDE; O82500; -.
DR EnsemblPlants; AT4G11170.1; AT4G11170.1; AT4G11170.
DR GeneID; 826718; -.
DR Gramene; AT4G11170.1; AT4G11170.1; AT4G11170.
DR KEGG; ath:AT4G11170; -.
DR Araport; AT4G11170; -.
DR TAIR; locus:2136108; AT4G11170.
DR eggNOG; ENOG502SUNR; Eukaryota.
DR HOGENOM; CLU_001561_0_1_1; -.
DR InParanoid; O82500; -.
DR OMA; NEADMIT; -.
DR OrthoDB; 99579at2759; -.
DR PhylomeDB; O82500; -.
DR PRO; PR:O82500; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O82500; baseline and differential.
DR Genevisible; O82500; AT.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0010193; P:response to ozone; IEP:TAIR.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; PTHR11017; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Leucine-rich repeat; NAD; Plant defense; Reference proteome;
KW Repeat.
FT CHAIN 1..1095
FT /note="Putative disease resistance protein At4g11170"
FT /id="PRO_0000262928"
FT DOMAIN 9..173
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT DOMAIN 168..454
FT /note="NB-ARC"
FT REPEAT 609..631
FT /note="LRR 1"
FT REPEAT 632..654
FT /note="LRR 2"
FT REPEAT 655..677
FT /note="LRR 3"
FT REPEAT 679..701
FT /note="LRR 4"
FT REPEAT 702..722
FT /note="LRR 5"
FT REPEAT 723..744
FT /note="LRR 6"
FT ACT_SITE 84
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
SQ SEQUENCE 1095 AA; 126083 MW; C18F6D90F2EEC62A CRC64;
MASSSSNSWR YDVFPSFRGE DVRNNFLSHL LKEFESKGIV TFRDDHIKRS HTIGHELRAA
IRESKISVVL FSENYASSSW CLDELIEIMK CKEEQGLKVM PVFYKVDPSD IRKQTGKFGM
SFLETCCGKT EERQHNWRRA LTDAANILGD HPQNWDNEAY KITTISKDVL EKLNATPSRD
FNDLVGMEAH IAKMESLLCL ESQGVRIVGI WGPAGVGKTT IARALYNQYH ENFNLSIFME
NVRESYGEAG LDDYGLKLHL QQRFLSKLLD QKDLRVRHLG AIEERLKSQK VLIILDDVDN
IEQLKALAKE NQWFGNKSRI VVTTQNKQLL VSHDINHMYQ VAYPSKQEAL TIFCQHAFKQ
SSPSDDLKHL AIEFTTLAGH LPLALRVLGS FMRGKGKEEW EFSLPTLKSR LDGEVEKVLK
VGYDGLHDHE KDLFLHIACI FSGQHENYLK QMIIANNDTY VSFGLQVLAD KSLIQKFENG
RIEMHSLLRQ LGKEVVRKQS IYEPGKRQFL MNAKETCGVL SNNTGTGTVL GISLDMCEIK
EELYISEKTF EEMRNLVYLK FYMSSPIDDK MKVKLQLPEE GLSYLPQLRL LHWDAYPLEF
FPSSFRPECL VELNMSHSKL KKLWSGVQPL RNLRTMNLNS SRNLEILPNL MEATKLNRLD
LGWCESLVEL PSSIKNLQHL ILLEMSCCKK LEIIPTNINL PSLEVLHFRY CTRLQTFPEI
STNIRLLNLI GTAITEVPPS VKYWSKIDEI CMERAKVKRL VHVPYVLEKL CLRENKELET
IPRYLKYLPR LQMIDISYCI NIISLPKLPG SVSALTAVNC ESLQILHGHF RNKSIHLNFI
NCLKLGQRAQ EKIHRSVYIH QSSYIADVLP GEHVPAYFSY RSTGSSIMIH SNKVDLSKFN
RFKVCLVLGA GKRFEGCDIK FYKQFFCKPR EYYVPKHLDS PLLKSDHLCM CEFELMPPHP
PTEWELLHPN EFLEVSFESR GGLYKCEVKE CGLQFLEPHE TSEFRYLSPH LYLGGSWIGN
SSSSIEEIIH VDQEESSSDS EEIIYADQEE SSSGIEEIIH AEREGTNRRK SVMRWIKVGA
RKMGLSLECL KPWTR
