CART_PIG
ID CART_PIG Reviewed; 66 AA.
AC Q9BDP9;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Cocaine- and amphetamine-regulated transcript protein;
DE Contains:
DE RecName: Full=CART(55-102);
DE Contains:
DE RecName: Full=CART(62-102);
DE Flags: Fragment;
GN Name=CARTPT; Synonyms=CART;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus;
RA Matteri R.L.;
RT "Sus scrofa cocaine- and amphetamine-regulated transcript (CART) cDNA.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Satiety factor closely associated with the actions of leptin
CC and neuropeptide y; this anorectic peptide inhibits both normal and
CC starvation-induced feeding and completely blocks the feeding response
CC induced by neuropeptide Y and regulated by leptin in the hypothalamus.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CART family. {ECO:0000305}.
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DR EMBL; AF338229; AAK26325.1; -; mRNA.
DR AlphaFoldDB; Q9BDP9; -.
DR SMR; Q9BDP9; -.
DR STRING; 9823.ENSSSCP00000017982; -.
DR PaxDb; Q9BDP9; -.
DR PeptideAtlas; Q9BDP9; -.
DR eggNOG; ENOG502S2YU; Eukaryota.
DR HOGENOM; CLU_157363_1_0_1; -.
DR InParanoid; Q9BDP9; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; Q9BDP9; SS.
DR GO; GO:0005615; C:extracellular space; ISS:HGNC-UCL.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0008343; P:adult feeding behavior; ISS:HGNC-UCL.
DR GO; GO:0001678; P:cellular glucose homeostasis; ISS:HGNC-UCL.
DR GO; GO:0009267; P:cellular response to starvation; ISS:HGNC-UCL.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR GO; GO:0032922; P:circadian regulation of gene expression; ISS:HGNC-UCL.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:HGNC-UCL.
DR GO; GO:0032099; P:negative regulation of appetite; ISS:HGNC-UCL.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISS:HGNC-UCL.
DR GO; GO:0032812; P:positive regulation of epinephrine secretion; ISS:HGNC-UCL.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:InterPro.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:HGNC-UCL.
DR GO; GO:0051971; P:positive regulation of transmission of nerve impulse; ISS:HGNC-UCL.
DR Gene3D; 4.10.40.30; -; 1.
DR InterPro; IPR009106; CART.
DR InterPro; IPR036722; CART_C_sf.
DR PANTHER; PTHR16655; PTHR16655; 1.
DR Pfam; PF06373; CART; 1.
DR SUPFAM; SSF64546; SSF64546; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Neuropeptide;
KW Neurotransmitter; Reference proteome; Secreted.
FT CHAIN 1..>66
FT /note="Cocaine- and amphetamine-regulated transcript
FT protein"
FT /id="PRO_0000045382"
FT PEPTIDE 21..>66
FT /note="CART(55-102)"
FT /evidence="ECO:0000250"
FT /id="PRO_0000004440"
FT PEPTIDE 28..>66
FT /note="CART(62-102)"
FT /evidence="ECO:0000250"
FT /id="PRO_0000004441"
FT DISULFID 34..52
FT /evidence="ECO:0000250"
FT DISULFID 40..60
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 66
SQ SEQUENCE 66 AA; 7451 MW; D217D4B6E94155F1 CRC64;
HEKELIEALQ EVLKKLKSKR IPIYEKKYGQ VPMCDAGEQC AVRKGARIGK LCDCPRGTSC
NSFLLK
