Y4121_ARATH
ID Y4121_ARATH Reviewed; 393 AA.
AC Q8L733; Q9SZ78;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Putative transferase At4g12130, mitochondrial {ECO:0000305};
DE EC=2.1.-.- {ECO:0000305};
DE AltName: Full=Iron-sulfur cluster assembly factor homolog COG0354 {ECO:0000305};
DE Flags: Precursor;
GN OrderedLocusNames=At4g12130 {ECO:0000312|Araport:AT4G12130};
GN ORFNames=F16J13.200 {ECO:0000312|EMBL:CAB40954.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION.
RX PubMed=20489182; DOI=10.1073/pnas.0911586107;
RA Waller J.C., Alvarez S., Naponelli V., Lara-Nunez A., Blaby I.K.,
RA Da Silva V., Ziemak M.J., Vickers T.J., Beverley S.M., Edison A.S.,
RA Rocca J.R., Gregory J.F., de Crecy-Lagard V., Hanson A.D.;
RT "A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in
RT all domains of life.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:10412-10417(2010).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=21984653; DOI=10.1093/jxb/err286;
RA Waller J.C., Ellens K.W., Alvarez S., Loizeau K., Ravanel S., Hanson A.D.;
RT "Mitochondrial and plastidial COG0354 proteins have folate-dependent
RT functions in iron-sulphur cluster metabolism.";
RL J. Exp. Bot. 63:403-411(2012).
CC -!- FUNCTION: Folate-dependent protein involved in Fe/S cluster biogenesis.
CC Functionally complements an E.coli mutant defective in ygfZ.
CC {ECO:0000269|PubMed:20489182, ECO:0000269|PubMed:21984653}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21984653}.
CC -!- TISSUE SPECIFICITY: Expressed in flowers, siliques and seeds (at
CC protein level). {ECO:0000269|PubMed:21984653}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality when homozygous.
CC {ECO:0000269|PubMed:21984653}.
CC -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB40954.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049638; CAB40954.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161533; CAB78256.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83099.1; -; Genomic_DNA.
DR EMBL; AY139983; AAM98126.1; -; mRNA.
DR EMBL; BT008478; AAP37837.1; -; mRNA.
DR PIR; T06620; T06620.
DR RefSeq; NP_192950.2; NM_117283.3.
DR AlphaFoldDB; Q8L733; -.
DR SMR; Q8L733; -.
DR STRING; 3702.AT4G12130.1; -.
DR PaxDb; Q8L733; -.
DR PRIDE; Q8L733; -.
DR ProteomicsDB; 243124; -.
DR EnsemblPlants; AT4G12130.1; AT4G12130.1; AT4G12130.
DR GeneID; 826821; -.
DR Gramene; AT4G12130.1; AT4G12130.1; AT4G12130.
DR KEGG; ath:AT4G12130; -.
DR Araport; AT4G12130; -.
DR TAIR; locus:2118041; AT4G12130.
DR eggNOG; KOG2929; Eukaryota.
DR HOGENOM; CLU_007884_7_0_1; -.
DR InParanoid; Q8L733; -.
DR OMA; MDRLHGV; -.
DR OrthoDB; 1342242at2759; -.
DR PhylomeDB; Q8L733; -.
DR PRO; PR:Q8L733; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8L733; baseline and differential.
DR Genevisible; Q8L733; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:TAIR.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR Gene3D; 3.30.1360.120; -; 1.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR InterPro; IPR045179; YgfZ/GcvT.
DR InterPro; IPR017703; YgfZ/GcvT_CS.
DR PANTHER; PTHR22602; PTHR22602; 1.
DR TIGRFAMs; TIGR03317; ygfZ_signature; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transferase; Transit peptide.
FT TRANSIT 1..70
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 71..393
FT /note="Putative transferase At4g12130, mitochondrial"
FT /evidence="ECO:0000255"
FT /id="PRO_0000433437"
SQ SEQUENCE 393 AA; 43528 MW; 0A955CCFD21BA4A6 CRC64;
MFRFNFRREI SKYTGIYHRK IHSGLEDAGP MASRLKSRSV VRFSGPDTVK FLQGLLTNDV
RRFGESSGEK NSAVPTPNMA SVTNPPMYAA LLTPQGRFLY DFFLYSPSRP DEKLDRTGSG
PGSDSGRDGS VELFADVDVD VLDELLETLK KYRLRSKVDI ENVAEEFSCW QRYGRNLTGS
SSVGWGGGVD RAGESTASGN KYGWQWYKDP RLECLGYRSI FPSDATPPLV EADKETDESN
YLLWRLEHGV AEGSAEIPKG EAIPLEYNFV GLNAISFDKG CYVGQELIAR THHRGVIRKR
LIPLRFIDSN GKELNQKIAA GAEVVESGTG KKMGTVSTAL GSRGMGVMRV EEAFKPSAEL
AVKDSEEVKV EAIKPTWWPA EWFQQNQSGV AAA
