ID   Y4158_STRCO             Reviewed;         340 AA.
AC   Q05954; Q9KZU3;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   18-OCT-2001, sequence version 2.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator SCO4158;
GN   OrderedLocusNames=SCO4158; ORFNames=SCD84.25c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66.
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=7688332; DOI=10.1016/0378-1119(93)90359-b;
RA   Wray L.V. Jr., Fisher S.H.;
RT   "The Streptomyces coelicolor glnR gene encodes a protein similar to other
RT   bacterial response regulators.";
RL   Gene 130:145-150(1993).
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DR   EMBL; AL939119; CAB88491.1; -; Genomic_DNA.
DR   EMBL; L03213; AAA02839.1; -; Unassigned_DNA.
DR   PIR; PN0644; PN0644.
DR   RefSeq; NP_628335.1; NC_003888.3.
DR   RefSeq; WP_003974813.1; NZ_VNID01000038.1.
DR   AlphaFoldDB; Q05954; -.
DR   SMR; Q05954; -.
DR   STRING; 100226.SCO4158; -.
DR   GeneID; 1099598; -.
DR   KEGG; sco:SCO4158; -.
DR   PATRIC; fig|100226.15.peg.4222; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_0_11; -.
DR   InParanoid; Q05954; -.
DR   OMA; YNRYDAY; -.
DR   PhylomeDB; Q05954; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..340
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   SCO4158"
FT                   /id="PRO_0000108010"
FT   DOMAIN          1..59
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   340 AA;  36767 MW;  35F32456E94E1A15 CRC64;
     MAKVTRDDVA RLAGTSTAVV SYVINNGPRP VAPATRERVL AAIKELGYRP DRVAQAMASR
     RTDLIGLIVP DARQPFFAEM AHAVEWAASE RGKMVLVGNS DYVGEREVHY LRAFLGMRVS
     GLILVSHALN DNAAAEIDAW DARVVLLHER PEAIDDVAVV TDDLGGAQLA VRHLLEHGYA
     YVACMGGTAE TPSVGDPVSD HVEGWRRAMK EAGLSTEGRL FEAPYNRYDA YRVGLELLSG
     PQRPPAIFCS TDDQAIGLLR AARELRIDVP GELAVAGFDD IKEADLADPP LTTVASDRSA
     MARSAVDLVL DDGLRVAGSR RERLKVFPSQ LVVRQSCGCA