ID   Y415_HELPJ              Reviewed;         623 AA.
AC   Q9ZKG7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Uncharacterized MscS family protein jhp_0969;
GN   OrderedLocusNames=jhp_0969;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD06551.1; -; Genomic_DNA.
DR   PIR; C71865; C71865.
DR   RefSeq; WP_001238066.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZKG7; -.
DR   SMR; Q9ZKG7; -.
DR   EnsemblBacteria; AAD06551; AAD06551; jhp_0969.
DR   KEGG; hpj:jhp_0969; -.
DR   PATRIC; fig|85963.30.peg.1625; -.
DR   eggNOG; COG0668; Bacteria.
DR   OMA; FRKEVIN; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.30.30.60; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR006685; MscS_channel.
DR   InterPro; IPR011066; MscS_channel_C.
DR   InterPro; IPR006686; MscS_channel_CS.
DR   InterPro; IPR011014; MscS_channel_TM-2.
DR   InterPro; IPR023408; MscS_dom_sf.
DR   InterPro; IPR045042; YnaI-like.
DR   PANTHER; PTHR43634; PTHR43634; 1.
DR   Pfam; PF00924; MS_channel; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   SUPFAM; SSF82689; SSF82689; 1.
DR   SUPFAM; SSF82861; SSF82861; 1.
DR   PROSITE; PS01246; UPF0003; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..623
FT                   /note="Uncharacterized MscS family protein jhp_0969"
FT                   /id="PRO_0000110250"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   623 AA;  71160 MW;  CB5E884513395D0C CRC64;
     MRLLLWWVLV LSLFLDPLRA VEEHETDAVD LFLIFNQINQ LNQVIETYKK NPERSAEISL
     YNTQKNDLIK SLTSKVLNER DKIGIDINQN LKEQEKIKKR LSKSIKGDDF YTFMKDRLSL
     DILLIDETLY RFIDKIRSSI DIFSEQKDVE SISDAFLLRL GQFKLYTFPK NLGNVKMHEL
     EQMFSDYELR LNTYTEVLRY IKNHPKEVLP KNLIMEVNMD FVLNKISKVL PFTAHSLQVS
     KIALALMILA LLLGLRKLIT WLLALLLDRI FEIMQRNKKM HVNVQSSIVS PVSVFLALFS
     CDVALDIFYY PNASPPKVSM WVGAVYIMLL AWLVIALFKG YGEALVTNVA TKSTHNFRKE
     VINLILKVVY FLIFIVALLG VLKQLGFNVS AIIASLGIGG LAVALAVKDV LANFFASVIL
     LLDNSFSQGD WIVCGEVEGT VVEMGLRRTT IRAFDNALLS VPNSELAGKP IRNWSRRKVG
     RRIKMEIGLT YSSSQSALQL CVKDIKEMLE NHPKIANGAD SALQNASDYR YMFKKDIVSI
     DDFLGYKNNL FVFLDQFADS SINILVYCFS KTVVWEEWLE VKEDVMLKIM GIVEKHHLSF
     AFPSQSLYVE SLPEVSLKEG AKI