ID   Y415_HELPY              Reviewed;         623 AA.
AC   O25170;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Uncharacterized MscS family protein HP_0415;
GN   OrderedLocusNames=HP_0415;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07481.1; -; Genomic_DNA.
DR   PIR; G64571; G64571.
DR   RefSeq; NP_207213.1; NC_000915.1.
DR   RefSeq; WP_001238108.1; NC_018939.1.
DR   AlphaFoldDB; O25170; -.
DR   SMR; O25170; -.
DR   DIP; DIP-3304N; -.
DR   IntAct; O25170; 2.
DR   MINT; O25170; -.
DR   TCDB; 1.A.23.4.10; the small conductance mechanosensitive ion channel (mscs) family.
DR   PaxDb; O25170; -.
DR   EnsemblBacteria; AAD07481; AAD07481; HP_0415.
DR   KEGG; hpy:HP_0415; -.
DR   PATRIC; fig|85962.47.peg.440; -.
DR   eggNOG; COG0668; Bacteria.
DR   OMA; FRKEVIN; -.
DR   PhylomeDB; O25170; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.30.30.60; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR006685; MscS_channel.
DR   InterPro; IPR011066; MscS_channel_C.
DR   InterPro; IPR006686; MscS_channel_CS.
DR   InterPro; IPR011014; MscS_channel_TM-2.
DR   InterPro; IPR023408; MscS_dom_sf.
DR   InterPro; IPR045042; YnaI-like.
DR   PANTHER; PTHR43634; PTHR43634; 1.
DR   Pfam; PF00924; MS_channel; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   SUPFAM; SSF82689; SSF82689; 1.
DR   SUPFAM; SSF82861; SSF82861; 1.
DR   PROSITE; PS01246; UPF0003; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..623
FT                   /note="Uncharacterized MscS family protein HP_0415"
FT                   /id="PRO_0000110249"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   623 AA;  71286 MW;  EC426BD5616AD342 CRC64;
     MRLLLWWVLV LSLFLNPLRA VEEHETDAVD LFLIFNQINQ LNQVIETYKK NPERSAEISL
     YNTQKNDLIK SLTSKVLNER DKIGIDINQN LKEQEKIKKR LSKSINGDDF YTFMKDRLSL
     DILLIDEILY RFIDKIRSSI DIFSEQKDVE SISDAFLLRL GQFKLYTFPK NLGNVKMHEL
     EQMFSDYELR LNTYTEVLRY IKNHPKEVLP KNLIMEVNMD FVLNKISKVL PFTTHSLQVS
     KIVLALTILA LLLGLRKLIT WLLALLLDRI FEIMQRNKKM HVNVQKSIVS PVSVFLALFS
     CDVALDIFYY PNASPPKVSM WVGAVYIMLL AWLVIALFKG YGEALVTNMA TKSTHNFRKE
     VINLILKVVY FLIFIVALLG VLKQLGFNVS AIIASLGIGG LAVALAVKDV LANFFASVIL
     LLDNSFSQGD WIVCGEVEGT VVEMGLRRTT IRAFDNALLS VPNSELAGKP IRNWSRRKVG
     RRIKMEIGLT YSSSQSALQL CVKDIKEMLE NHPKIANGAD SALQNVSDYR YMFKKDIVSI
     DDFLGYKNNL FVFLDQFADS SINILVYCFS KTVVWEEWLE VKEDVMLKIM GIVEKHHLSF
     AFPSQSLYVE SLPEVSLKEG AKI