ID   Y4189_MYCPA             Reviewed;         304 AA.
AC   Q73S87;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_4189c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_4189c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS06739.1; -; Genomic_DNA.
DR   RefSeq; WP_003873489.1; NC_002944.2.
DR   AlphaFoldDB; Q73S87; -.
DR   SMR; Q73S87; -.
DR   STRING; 262316.MAP_4189c; -.
DR   EnsemblBacteria; AAS06739; AAS06739; MAP_4189c.
DR   KEGG; mpa:MAP_4189c; -.
DR   PATRIC; fig|262316.17.peg.4461; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; FFIKMMD; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..304
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_4189c"
FT                   /id="PRO_0000361187"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..160
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   304 AA;  33240 MW;  574592B1C719B49F CRC64;
     MTRTHDDEWD LASSVGATAT MVAAGRAMAT KDPRGLIDDP FAEPLVRAVG VDFFTKMMDG
     ELDLDAIENA TPVRIQSMVD GMAVRTKYFD DYFVDATDAG VRRVVILASG LDSRAYRLPW
     PAGTVVYEID QPRVIEFKSN TLAEVGAEPT ATRRTIPIDL RGDWPAALSA AGFDPAAPTA
     WLAEGLLIYL PPEAQDRLFD NITALSAPGS TIATEFVPGI VDFDAERVRE MSGSFRQHGV
     DIDMASLVYA GERNHVIDYL NGLGWRAEGV TRTELFHRHG IEVPAPENDD PLGEIIFISA
     TRTR