Y418_HAEIN
ID Y418_HAEIN Reviewed; 447 AA.
AC P44699;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Putative metabolite transport protein HI_0418;
GN OrderedLocusNames=HI_0418;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Metabolite:H+
CC Symporter (MHS) family (TC 2.A.1.6) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L42023; AAC22076.1; -; Genomic_DNA.
DR PIR; B64152; B64152.
DR RefSeq; NP_438580.1; NC_000907.1.
DR AlphaFoldDB; P44699; -.
DR SMR; P44699; -.
DR STRING; 71421.HI_0418; -.
DR TCDB; 2.A.1.6.12; the major facilitator superfamily (mfs).
DR EnsemblBacteria; AAC22076; AAC22076; HI_0418.
DR KEGG; hin:HI_0418; -.
DR PATRIC; fig|71421.8.peg.438; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_001265_39_5_6; -.
DR OMA; ACMKETA; -.
DR PhylomeDB; P44699; -.
DR BioCyc; HINF71421:G1GJ1-433-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004736; MHS_symport.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00883; 2A0106; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..447
FT /note="Putative metabolite transport protein HI_0418"
FT /id="PRO_0000050489"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..63
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..119
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..194
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..295
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..354
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..390
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 412..418
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 440..447
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 447 AA; 48229 MW; EE9780E9060110CC CRC64;
MCKPQQKHYG RQVMNTQNSL KQVATATMVG TAIEYFDNYI YAMAAVLVFN HQFFHAVDPL
SGQIAALSTL ALTFIARPLG AILFGHFGDR FGRKNTFVMS LLLMGISTVV IGLLPTYDSI
GIWATILLCL CRIGQGIGLG GEWGGAALVA VENAPEGKRG WYGTFPQLGA PLGLLLANGV
FLGITAIFGQ EAMTEWAWRI PFLSSVILVA IGLYVRLKLT EAPIFLAALN KPKPKRLPML
EVVTTHFKPF FLGMLVCIAG YVLFYIMIAF SQIYAKSAPT VSEAGYAMGL GFSPQIFTAL
LMASAVSLAI TIAASGKYID KIGRRTWLIW TTVGVAIFGL SLPLFLENGT TTSLFWFLFI
GMGLIGMGYG PLASFLPELF PTHARYSGAS LTYNIAGLFG ASVAAIIALP LNAHYGLKGV
GIYLTLNAVL SLVGLWFISE TKDKLLS
