ID   Y4190_MYCPA             Reviewed;         306 AA.
AC   Q73S86;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_4190c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_4190c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS06740.1; -; Genomic_DNA.
DR   RefSeq; WP_003873488.1; NC_002944.2.
DR   AlphaFoldDB; Q73S86; -.
DR   SMR; Q73S86; -.
DR   STRING; 262316.MAP_4190c; -.
DR   EnsemblBacteria; AAS06740; AAS06740; MAP_4190c.
DR   KEGG; mpa:MAP_4190c; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; TEHVPDP; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..306
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_4190c"
FT                   /id="PRO_0000361188"
FT   BINDING         129
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         158..159
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   306 AA;  33670 MW;  77C78468D7A05D05 CRC64;
     MSEGRTDGDT WGPAQSVGAT ATMVAAARAV ASQGPDALLD DPLAEPLVRA VGLDPFIRIV
     EGKLDFPDDP LFNRRARAEQ ITVRTRFFDD FFIDATEAGL RQAVILASGL DTRAYRLTWP
     AGTVVYEIDQ PQVIAFKTDT LANLGAAPTA ERRTISIDLR DDWPAALREG GFDVTRPTAW
     SAEGLLPYLP PEAQDRLFDN ITALSAPGSR LATEHVPDPN AFSDERLARI SERWQRLGLN
     LNAADLFYRG ERNVVADYLT GKGWRVTPHP ARQLYARNGF EFPEDEMRAT FGEMSYVDAT
     LTGGRG