ID   Y4191_MYCPA             Reviewed;         314 AA.
AC   Q73S85;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_4191c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_4191c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS06741.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016958; AAS06741.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_015632742.1; NC_002944.2.
DR   AlphaFoldDB; Q73S85; -.
DR   SMR; Q73S85; -.
DR   STRING; 262316.MAP_4191c; -.
DR   EnsemblBacteria; AAS06741; AAS06741; MAP_4191c.
DR   KEGG; mpa:MAP_4191c; -.
DR   PATRIC; fig|262316.17.peg.4463; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; RMADNMA; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..314
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_4191c"
FT                   /id="PRO_0000361189"
FT   BINDING         138
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         167..168
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   314 AA;  33861 MW;  22904ACCFBBA7A79 CRC64;
     MTSTRYEGDT WDLASSVGVT ATMVAAARAM ATRADNPLIN DLFAEPLVKA VGVDLLSRLA
     GGELDPAELN DVHDGAAGSA GAMSRMADNM AVRTKFFDEF FLNATKAGIA QVVILASGLD
     ARAYRLAWPA GTVVYEVDQP QVIDFKTTAL AQLGAAPTAE RRVVAVDLRD DWPAALRAAG
     FDPARPTAWS AEGLLGYLPP EAQDRLLDTI TELSAPGSRL ATESAPNPAP GEEEKLKERM
     QAISQRWRAH GFDLDMAGLV YFGERNEAAP YLAGHGWRLN SVTIRDLFAA NGLDPLDDDD
     TRMGEMLYTW GIYE