ID   Y4197_MYCPA             Reviewed;         303 AA.
AC   Q73S79;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_4197c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_4197c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS06747.1; -; Genomic_DNA.
DR   RefSeq; WP_003873481.1; NC_002944.2.
DR   AlphaFoldDB; Q73S79; -.
DR   SMR; Q73S79; -.
DR   STRING; 262316.MAP_4197c; -.
DR   EnsemblBacteria; AAS06747; AAS06747; MAP_4197c.
DR   KEGG; mpa:MAP_4197c; -.
DR   PATRIC; fig|262316.17.peg.4469; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; QDSWDLA; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..303
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_4197c"
FT                   /id="PRO_0000361190"
FT   BINDING         129
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         158..159
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  33357 MW;  FF1CBD2DF3182D0D CRC64;
     MTRTDQDSWD LASSVGATAT MVAAARALAS TGERPIINDP FAAPLVRAVG LDFFRRLVDG
     EVAPADPQRG ERDLQLETDS IAVRTRFFDD FFTGAARDGI RQSVILAAGL DARAYRLDWP
     AGAVVYEVDQ PKVVEFKTNT MAALDARPAA QLRTVSIDLR EDWPEALRAN GFDVTQPTSW
     SAEGLLMYLP PEAQDRLFDN ITALSAPGSR LATEYHPDAT GTTMAQRAQE FNDRWARVGC
     DIDLSGLFFD GERSNVVEYL TGRGWRVSAR PRRDLFDDYG LAYPEDDETA QFPNIVAVSA
     ELG