ID   Y4205_MYCGI             Reviewed;         279 AA.
AC   A4TE41;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Uncharacterized oxidoreductase Mflv_4205;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Mflv_4205;
OS   Mycolicibacterium gilvum (strain PYR-GCK) (Mycobacterium gilvum (strain
OS   PYR-GCK)).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350054;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PYR-GCK;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; CP000656; ABP46674.1; -; Genomic_DNA.
DR   RefSeq; WP_011895049.1; NC_009338.1.
DR   AlphaFoldDB; A4TE41; -.
DR   SMR; A4TE41; -.
DR   STRING; 350054.Mflv_4205; -.
DR   EnsemblBacteria; ABP46674; ABP46674; Mflv_4205.
DR   KEGG; mgi:Mflv_4205; -.
DR   eggNOG; COG0656; Bacteria.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   OMA; KLWPTDQ; -.
DR   OrthoDB; 1035565at2; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..279
FT                   /note="Uncharacterized oxidoreductase Mflv_4205"
FT                   /id="PRO_0000380734"
FT   ACT_SITE        54
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         112
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         192..244
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   279 AA;  29813 MW;  053C5091269EE54A CRC64;
     MTSAAAIPTV TLNDDNTMPV IGLGVGELSD AETEQAVTAA LEAGYRLIDT AAAYGNEAAV
     GRAIAASGVP RDELFVTTKL ATEDAGFQSS QDALRASLER LGLDYVDLYL IHWPVSQQGK
     HVDSWGGLMK SKEVGLTRSI GVANFHGHHL DDIISLSFFT PAVNQIELHP LLNQAELRAV
     NAEHGIATEA YGPLGVGNLL SHSAVNAIAE AHGRTPAQVL IRWSLQLGNI VIPRSSSPER
     IRSNIDVFGF ELSEEQMSTL NGLDDGTRFR PDPETYSGS