ID   Y4207_MYCS2             Reviewed;         130 AA.
AC   A0QZZ6;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Universal stress protein MSMEG_4207;
DE            Short=Usp;
GN   OrderedLocusNames=MSMEG_4207, MSMEI_4109;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
RN   [4]
RP   ACETYLATION AT LYS-104, MUTAGENESIS OF LYS-104, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=22773105; DOI=10.1038/nsmb.2318;
RA   Lee H.J., Lang P.T., Fortune S.M., Sassetti C.M., Alber T.;
RT   "Cyclic AMP regulation of protein lysine acetylation in Mycobacterium
RT   tuberculosis.";
RL   Nat. Struct. Mol. Biol. 19:811-818(2012).
CC   -!- PTM: Acetylated on Lys-104 by PatA in the presence of acetyl-CoA as an
CC       acetyl donor. {ECO:0000269|PubMed:22773105}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; CP000480; ABK72172.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP40566.1; -; Genomic_DNA.
DR   RefSeq; WP_011729640.1; NZ_SIJM01000003.1.
DR   RefSeq; YP_888484.1; NC_008596.1.
DR   AlphaFoldDB; A0QZZ6; -.
DR   SMR; A0QZZ6; -.
DR   STRING; 246196.MSMEI_4109; -.
DR   iPTMnet; A0QZZ6; -.
DR   EnsemblBacteria; ABK72172; ABK72172; MSMEG_4207.
DR   EnsemblBacteria; AFP40566; AFP40566; MSMEI_4109.
DR   GeneID; 66735554; -.
DR   KEGG; msg:MSMEI_4109; -.
DR   KEGG; msm:MSMEG_4207; -.
DR   PATRIC; fig|246196.19.peg.4128; -.
DR   eggNOG; COG0589; Bacteria.
DR   OMA; TVETHQL; -.
DR   OrthoDB; 2040681at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PRINTS; PR01438; UNVRSLSTRESS.
PE   1: Evidence at protein level;
KW   Acetylation; Reference proteome.
FT   CHAIN           1..130
FT                   /note="Universal stress protein MSMEG_4207"
FT                   /id="PRO_0000420363"
FT   MOD_RES         104
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000269|PubMed:22773105"
FT   MUTAGEN         104
FT                   /note="K->R: No acetylation is observed."
FT                   /evidence="ECO:0000269|PubMed:22773105"
SQ   SEQUENCE   130 AA;  13960 MW;  5ABBB51750EEDCF5 CRC64;
     MIVVGYSADP FGRAAVEHGI EEAKRRDTGL LVINATAGDA YVDARFARSG EVHDVEAHLQ
     DSGVPFEIRQ PVGVDATEEL LTAMDSPDAE LLVIGIRHRN PVGKLLLGSV AQRLLLECPK
     PVLAVKPHGF