ID   Y421_METTH              Reviewed;         385 AA.
AC   O26521;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Uncharacterized protein MTH_421;
GN   OrderedLocusNames=MTH_421;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.jannaschii MJ0835.2. {ECO:0000305}.
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DR   EMBL; AE000666; AAB84927.1; -; Genomic_DNA.
DR   PIR; H69154; H69154.
DR   AlphaFoldDB; O26521; -.
DR   STRING; 187420.MTH_421; -.
DR   EnsemblBacteria; AAB84927; AAB84927; MTH_421.
DR   KEGG; mth:MTH_421; -.
DR   HOGENOM; CLU_716919_0_0_2; -.
DR   OMA; WKDIIPS; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   InterPro; IPR009639; Pept_A24A_C_arc.
DR   InterPro; IPR000045; Prepilin_IV_endopep_pep.
DR   Pfam; PF06819; Arc_PepC; 1.
DR   Pfam; PF01478; Peptidase_A24; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..385
FT                   /note="Uncharacterized protein MTH_421"
FT                   /id="PRO_0000107072"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   385 AA;  43349 MW;  37A14F7C32F46DDF CRC64;
     MILMVIELLS VFIALLACFY ASYSDIKRGI IPNRLTFPVI GLGLLLNGAR ALMESDPWIF
     IYTAIFTAGI FALGYILWRM VAWAGGDVKL FTAVTSLLPF QPSLVSYSFL GTAFPVTASY
     PFPLTVIINS ILALLPFLLV YVFFIIYTSR RHLMDEFMEP LRQYRTSMVL ALVITSAVTL
     TFLITDFLPF QIIVLSLILV YLLTMVISRL PPRIKAVIVS VIIVYSLYKN FELTVSGVVI
     LWVSITVIQL IRKLLTSITR EALQDTMGVD ELKEGMILAS TLYRKGDEYY FDDSSLLDRF
     RTAARTGDVS ALTYRGEPVV SAMAAGLREE EIETLRDLVS RGKIKDEFRI RRGMPFAPAI
     FIGLLVSLLI GDLAMILFRL FDIIF