ID   Y424_HAEIN              Reviewed;         351 AA.
AC   P44703;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Uncharacterized tRNA/rRNA methyltransferase HI_0424;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=HI_0424;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22080.1; -; Genomic_DNA.
DR   PIR; D64152; D64152.
DR   RefSeq; NP_438585.1; NC_000907.1.
DR   RefSeq; WP_005693740.1; NC_000907.1.
DR   AlphaFoldDB; P44703; -.
DR   SMR; P44703; -.
DR   STRING; 71421.HI_0424; -.
DR   PRIDE; P44703; -.
DR   DNASU; 949529; -.
DR   EnsemblBacteria; AAC22080; AAC22080; HI_0424.
DR   KEGG; hin:HI_0424; -.
DR   PATRIC; fig|71421.8.peg.444; -.
DR   eggNOG; COG0566; Bacteria.
DR   HOGENOM; CLU_021322_2_1_6; -.
DR   OMA; NRAEEMK; -.
DR   PhylomeDB; P44703; -.
DR   BioCyc; HINF71421:G1GJ1-439-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0001510; P:RNA methylation; IBA:GO_Central.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   InterPro; IPR016479; YfiF_prd.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   PANTHER; PTHR46429:SF2; PTHR46429:SF2; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   PIRSF; PIRSF006280; YfiF_prd; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..351
FT                   /note="Uncharacterized tRNA/rRNA methyltransferase HI_0424"
FT                   /id="PRO_0000159816"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  39397 MW;  71FA2E679F64AE4C CRC64;
     MNDKRKPSFQ SAGKTFQERS VGEKYREKPT QNRPHFNDKF NGNRNEKSRF PRDKQEVKET
     RITQLSLSRA PSNKNAEQPK VQVTIKSTGT VYKTKEKKTG ALSPRAPEKI KKNRAEEMKV
     YGENACLALF AERPESIVRL WATVQMSHKI GEVLSYLAEN KKAYHVVDSE ELARVSGTEH
     HGGICLLVKK PRAFTLQGYL DIPRNEDCLV LLDNVNNAQN IGGVLRTCAY FGVKNIVADN
     VENLYSAASM RVAEGGAEYI RVLEADYIDS ALMQLRKSGY QIIHVSHNKQ GDPLDKVRLK
     NKVVFVLSES STESLATPED TQARLTLASP IKSGLNIAVN AGVLLAKWYF R