Y425_MYCGE
ID Y425_MYCGE Reviewed; 449 AA.
AC P47664;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Probable ATP-dependent RNA helicase MG425;
DE EC=3.6.4.13;
GN OrderedLocusNames=MG425;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 257-326.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L43967; AAC72446.1; -; Genomic_DNA.
DR EMBL; U01805; AAD12332.1; -; Genomic_DNA.
DR PIR; I64246; I64246.
DR RefSeq; WP_009885607.1; NZ_AAGX01000001.1.
DR AlphaFoldDB; P47664; -.
DR SMR; P47664; -.
DR STRING; 243273.MG_425; -.
DR EnsemblBacteria; AAC72446; AAC72446; MG_425.
DR KEGG; mge:MG_425; -.
DR eggNOG; COG0513; Bacteria.
DR HOGENOM; CLU_003041_1_3_14; -.
DR OMA; YDIELYQ; -.
DR OrthoDB; 643629at2; -.
DR BioCyc; MGEN243273:G1GJ2-519-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0033592; F:RNA strand annealing activity; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW RNA-binding.
FT CHAIN 1..449
FT /note="Probable ATP-dependent RNA helicase MG425"
FT /id="PRO_0000055114"
FT DOMAIN 34..205
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 233..383
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 427..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 3..31
FT /note="Q motif"
FT MOTIF 153..156
FT /note="DEID box"
FT BINDING 47..54
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 449 AA; 51254 MW; AF45553BFA705558 CRC64;
MDSTFHELGI SQTLIETLNA LHINKPTKIQ QISIPQFLSE KNLIVHSPTG TGKTAAFAIP
IIEKLLKEDQ TAKPTLVIAP TRELVEQIKT TFSNIAKNKK LRIISLIGGV PAWKQIKKIK
TNPQIIVGTM GRIMDLLERK AIHFSDLEHL IIDEVDLMLD RGFKKQIFNL LEQINSFKQI
AVYSASYNQE AINIAKQITN NGIFIGSPEF NKDANTNNDK LIKQFVCYLF SDQKKQALYS
LIKTAQVKSI IVFCDTKKLV DDLHVFLRKN ELRTFALHGD KKQFIRERNL KIFANTKQPT
ILVTTDLIGR GIHVEAIDMV INYSACLNLE AYINRMGRTG RNNHKGTCVT FCTSQEKKVF
LKMVEKITDN RIAECKQMEI KLIPLKNKAK TKKGGISLDC VQKIYANAKP YDRNKRVPLA
SDLFKSRMRQ PEKAMQKQKI HDNDWQSNM
