ID   Y4267_DICDI             Reviewed;         667 AA.
AC   Q86J11; C7FZZ1; Q555T8; Q555T9; Q86J10;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Kelch repeat-containing protein DDB_G0274267;
GN   ORFNames=DDB_G0274267;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
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DR   EMBL; AAFI02000012; EEU04128.1; -; Genomic_DNA.
DR   RefSeq; XP_002649180.2; XM_002649134.1.
DR   AlphaFoldDB; Q86J11; -.
DR   SMR; Q86J11; -.
DR   STRING; 44689.DDB0304412; -.
DR   PaxDb; Q86J11; -.
DR   GeneID; 8619398; -.
DR   KEGG; ddi:DDB_G0274267; -.
DR   dictyBase; DDB_G0274267; -.
DR   eggNOG; ENOG502RI24; Eukaryota.
DR   HOGENOM; CLU_411867_0_0_1; -.
DR   InParanoid; Q86J11; -.
DR   OMA; MDNDFTS; -.
DR   Reactome; R-DDI-4641258; Degradation of DVL.
DR   Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR   Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q86J11; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   Gene3D; 2.120.10.80; -; 1.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   SMART; SM00612; Kelch; 2.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF50965; SSF50965; 1.
PE   4: Predicted;
KW   Coiled coil; Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..667
FT                   /note="Kelch repeat-containing protein DDB_G0274267"
FT                   /id="PRO_0000364031"
FT   REPEAT          319..366
FT                   /note="Kelch 1"
FT   REPEAT          369..412
FT                   /note="Kelch 2"
FT   REPEAT          434..480
FT                   /note="Kelch 3"
FT   REPEAT          484..531
FT                   /note="Kelch 4"
FT   REPEAT          534..582
FT                   /note="Kelch 5"
FT   REPEAT          607..654
FT                   /note="Kelch 6"
FT   REGION          248..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          58..98
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   667 AA;  75621 MW;  0FD2B8156CF3E5B3 CRC64;
     MIENEEFKNL NDHWRNTIEK LSIYKDISEQ TLERCDESFI ETKKKICQDF DTIINYLTDR
     KIELLQQLGE ELEAHKQQIE SNRDKSMMLI EQLNKKMNSP SKFDININSS GGGGSGGVVF
     SGGGGGGLSH STSYSGNLSN YLSASSGFAS SPLNYSTSSL MVTNNNNNNP MTSPLKKSTS
     FQTDYLQVLK ESISYIEWDW KDEFQENNTT NRKIIKQPKP ISSMASDLIL NSSFKSFDDL
     NKKFQEFSNN NDDTDDYDNN NNNNNDNKDD FDNCENNNNG DSLKMKSNKK LKIFGKLKFK
     IIETLEYKRL NSNLEDTKCI YSIGGKCKDG FDQYSIEKFD FKQGLWRSLQ SIPSIMDNDF
     TGNFDGKNHI YLFGGSLQPT RILKYNLLED QWEIIETNNN NNNNNNGANG ANGNIEIPDN
     GRFLHCSVFD GKQNIYLIGG FPRSTSILKF NIITEQFSKQ QSKSTTSSRN LWSMGAIYKE
     DNNSIYLIGG CNITRQSVDT LERYDIDNDS FTTLSPLPVS CYGAGVFYDD QEHYIYVLGG
     YNSKENKCLS IIQRYDLLDN SWSVLTNNHD DDDDDDGDSG GGLQNLLLPK PMMINGNSII
     FDSSKRIVHI LGGYNNVTKE SIDDIYTLDI SNILDENLSN KINWEVNKIP QFKNSKFKGG
     TSILVQK