Y4291_ARATH
ID Y4291_ARATH Reviewed; 913 AA.
AC C0LGR6; Q9SZE6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At4g29180;
DE EC=2.7.11.1;
DE Flags: Precursor;
GN OrderedLocusNames=At4g29180; ORFNames=F19B15.210;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT like protein kinase genes in Arabidopsis thaliana.";
RL BMC Genomics 11:19-19(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- INTERACTION:
CC C0LGR6; Q9SH71: At1g64210; NbExp=2; IntAct=EBI-20654480, EBI-20651385;
CC C0LGR6; Q9M9C5: At1g68400; NbExp=2; IntAct=EBI-20654480, EBI-1238661;
CC C0LGR6; C0LGL4: At2g28960; NbExp=2; IntAct=EBI-20654480, EBI-16946048;
CC C0LGR6; Q9SUQ3: At4g23740; NbExp=2; IntAct=EBI-20654480, EBI-16912451;
CC C0LGR6; C0LGR9: At4g31250; NbExp=2; IntAct=EBI-20654480, EBI-16955262;
CC C0LGR6; A0A1P8B6S7: At4g39270; NbExp=2; IntAct=EBI-20654480, EBI-20661308;
CC C0LGR6; Q8W4S5: At5g63710; NbExp=2; IntAct=EBI-20654480, EBI-16934827;
CC C0LGR6; O65440-2: BAM3; NbExp=2; IntAct=EBI-20654480, EBI-20653325;
CC C0LGR6; C0LGQ5: GSO1; NbExp=2; IntAct=EBI-20654480, EBI-16905069;
CC C0LGR6; Q9LJM4: IKU2; NbExp=2; IntAct=EBI-20654480, EBI-20664220;
CC C0LGR6; F4K6B8: RGI4; NbExp=2; IntAct=EBI-20654480, EBI-1238236;
CC C0LGR6; Q9LP77: RKL1; NbExp=2; IntAct=EBI-20654480, EBI-1544507;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=C0LGR6-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB43932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79676.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL078470; CAB43932.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161574; CAB79676.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85599.1; -; Genomic_DNA.
DR EMBL; FJ708757; ACN59351.1; -; mRNA.
DR PIR; T08973; T08973.
DR RefSeq; NP_001190865.1; NM_001203936.2. [C0LGR6-1]
DR AlphaFoldDB; C0LGR6; -.
DR SMR; C0LGR6; -.
DR BioGRID; 14326; 53.
DR IntAct; C0LGR6; 65.
DR STRING; 3702.AT4G29180.2; -.
DR PaxDb; C0LGR6; -.
DR PRIDE; C0LGR6; -.
DR EnsemblPlants; AT4G29180.2; AT4G29180.2; AT4G29180. [C0LGR6-1]
DR GeneID; 829039; -.
DR Gramene; AT4G29180.2; AT4G29180.2; AT4G29180. [C0LGR6-1]
DR KEGG; ath:AT4G29180; -.
DR Araport; AT4G29180; -.
DR TAIR; locus:2119896; AT4G29180.
DR eggNOG; ENOG502QQCZ; Eukaryota.
DR HOGENOM; CLU_000288_41_1_1; -.
DR InParanoid; C0LGR6; -.
DR OMA; MSCVKDR; -.
DR PhylomeDB; C0LGR6; -.
DR PRO; PR:C0LGR6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; C0LGR6; baseline and differential.
DR Genevisible; C0LGR6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR024788; Malectin-like_Carb-bd_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF12819; Malectin_like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Glycoprotein; Kinase;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein;
KW Receptor; Reference proteome; Repeat; Serine/threonine-protein kinase;
KW Signal; Transferase; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..913
FT /note="Probable LRR receptor-like serine/threonine-protein
FT kinase At4g29180"
FT /id="PRO_0000387554"
FT TOPO_DOM 23..509
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 531..913
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 413..434
FT /note="LRR 1"
FT REPEAT 437..460
FT /note="LRR 2"
FT REPEAT 461..482
FT /note="LRR 3"
FT DOMAIN 567..877
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 862..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 704
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 573..581
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 595
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 558
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 653
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 739
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 744
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 752
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 408
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 434
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 471
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 724
FT /note="G -> W (in Ref. 3; ACN59351)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 913 AA; 101593 MW; 204B4F336D82455C CRC64;
MGAHSVFLIL FSVIAIAIVV HGQGQAGFIS IDCGSPPNIN YVDTDTGISY TWDAPFINAG
VNLNVSEEYG YPKNPVLPFP LADVRSFPQG NRNCYTLTPS DGKGNLYLIR ASFMYGNYDG
KNALPEFDLY VNVNFWTSVK LRNASENVIK EILSFAESDT IYVCLVNKGK GTPFISALEL
RPMNSSIYGT EFGRNVSLVL YQRWDTGYLN GTGRYQKDTY DRIWSPYSPV SWNTTMTTGY
IDIFQSGYRP PDEVIKTAAS PKSDDEPLEL SWTSSDPDTR FYAYLYFAEL ENLKRNESRE
IKIFWNGSPV SGAFNPSPEY SMTVSNSRAF TGKDHWISVQ KTAESTRPPI LNAIEIFSAQ
SLDEFYTRID DVQAIESIKS TYKVNKIWTG DPCSPRLFPW EGIGCSYNTS SYQIKSLNLS
SSGLHGPIAF AFRNLSLLES LDLSNNNLKG IVPEFLADLK YLKSLNLKGN NLTGFIPRSL
RKRATANGLA LSVDEQNICH SRSCRDGNRI MVPIVVSTLV IILIAALAII CIMRRESKIM
YSGAYSGPLL PSGKRRFTYS EVSSITNNFN KVIGKGGFGI VYLGSLEDGT EIAVKMINDS
SFGKSKGSSS SSSSSQVSKE FQVEAELLLT VHHRNLASFV GYCDDGRSMA LIYEYMANGN
LQDYLSSENA EDLSWEKRLH IAIDSAQGLE YLHHGCRPPI VHRDVKTANI LLNDNLEAKI
ADFGLSKVFP EDDLSHVVTA VMGTPGYVDP EYYNTFKLNE KSDVYSFGIV LLELITGKRS
IMKTDDGEKM NVVHYVEPFL KMGDIDGVVD PRLHGDFSSN SAWKFVEVAM SCVRDRGTNR
PNTNQIVSDL KQCLAAELAR EPKSNHEKKE VVKEKYTKTK STVQNYSSNE YNSSSGSVSL
SFGDYSTFGP MAR
