ID   Y4343_METS4             Reviewed;         236 AA.
AC   B0UHD1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=UPF0173 metal-dependent hydrolase M446_4343 {ECO:0000255|HAMAP-Rule:MF_00457};
GN   OrderedLocusNames=M446_4343;
OS   Methylobacterium sp. (strain 4-46).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4-46;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium sp. 4-46.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UPF0173 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00457}.
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DR   EMBL; CP000943; ACA18686.1; -; Genomic_DNA.
DR   RefSeq; WP_012334075.1; NC_010511.1.
DR   AlphaFoldDB; B0UHD1; -.
DR   SMR; B0UHD1; -.
DR   STRING; 426117.M446_4343; -.
DR   EnsemblBacteria; ACA18686; ACA18686; M446_4343.
DR   KEGG; met:M446_4343; -.
DR   eggNOG; COG2220; Bacteria.
DR   HOGENOM; CLU_070010_4_0_5; -.
DR   OMA; WHGHSTW; -.
DR   OrthoDB; 767622at2; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.60.15.10; -; 1.
DR   HAMAP; MF_00457; UPF0173; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR022877; UPF0173.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..236
FT                   /note="UPF0173 metal-dependent hydrolase M446_4343"
FT                   /id="PRO_0000367191"
SQ   SEQUENCE   236 AA;  24733 MW;  A9FABACD52655B69 CRC64;
     MRITWFGHSA FRLDFGESHV LIDPFFTGNP AFEGGDAARA RAVEGATHIL ITHGHGDHVG
     DTLAVAAETG AKVVTNYDLC MWLGSKGLTN FDPMNTGGTT DQGGFKVTLV RADHSAGMSE
     AGVTVPLGLP NGVVVRAPGE PTVYHMGDTD IFGDMALIQE IYRPDVLIVP IGDRFTMGAE
     TAALAVRKFF APRAVIPCHY GSFPIIAASA DAFVAALDGS GVQVVVPHKG TAVTIA