Y4374_ARATH
ID Y4374_ARATH Reviewed; 638 AA.
AC Q9SUQ3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Probable inactive receptor kinase At4g23740;
DE Flags: Precursor;
GN OrderedLocusNames=At4g23740; ORFNames=F9D16.210;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- INTERACTION:
CC Q9SUQ3; A0A178WLG7: At1g51790; NbExp=2; IntAct=EBI-16912451, EBI-20652336;
CC Q9SUQ3; C0LGH8: At1g63430; NbExp=3; IntAct=EBI-16912451, EBI-20657656;
CC Q9SUQ3; C0LGR6: At4g29180; NbExp=2; IntAct=EBI-16912451, EBI-20654480;
CC Q9SUQ3; A0A178UAF6: AXX17_At5g67350; NbExp=2; IntAct=EBI-16912451, EBI-20661274;
CC Q9SUQ3; Q9FZ59: PEPR2; NbExp=2; IntAct=EBI-16912451, EBI-20652612;
CC Q9SUQ3; Q9S7I6: RPK2; NbExp=4; IntAct=EBI-16912451, EBI-16940204;
CC Q9SUQ3; Q9FII5: TDR; NbExp=3; IntAct=EBI-16912451, EBI-15730235;
CC Q9SUQ3; P43298: TMK1; NbExp=3; IntAct=EBI-16912451, EBI-2023970;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. {ECO:0000305}.
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DR EMBL; AL035394; CAA23040.1; -; Genomic_DNA.
DR EMBL; AL161560; CAB81292.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84800.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66660.1; -; Genomic_DNA.
DR EMBL; BT008579; AAP40406.1; -; mRNA.
DR EMBL; AK118364; BAC42978.1; -; mRNA.
DR PIR; T05606; T05606.
DR RefSeq; NP_001328543.1; NM_001341629.1.
DR RefSeq; NP_194105.1; NM_118505.5.
DR AlphaFoldDB; Q9SUQ3; -.
DR SMR; Q9SUQ3; -.
DR BioGRID; 13763; 74.
DR IntAct; Q9SUQ3; 75.
DR STRING; 3702.AT4G23740.1; -.
DR iPTMnet; Q9SUQ3; -.
DR PaxDb; Q9SUQ3; -.
DR PRIDE; Q9SUQ3; -.
DR ProteomicsDB; 242878; -.
DR EnsemblPlants; AT4G23740.1; AT4G23740.1; AT4G23740.
DR EnsemblPlants; AT4G23740.2; AT4G23740.2; AT4G23740.
DR GeneID; 828474; -.
DR Gramene; AT4G23740.1; AT4G23740.1; AT4G23740.
DR Gramene; AT4G23740.2; AT4G23740.2; AT4G23740.
DR KEGG; ath:AT4G23740; -.
DR Araport; AT4G23740; -.
DR TAIR; locus:2128414; AT4G23740.
DR eggNOG; ENOG502QTFK; Eukaryota.
DR HOGENOM; CLU_000288_92_6_1; -.
DR InParanoid; Q9SUQ3; -.
DR OMA; CNEDGSR; -.
DR OrthoDB; 507883at2759; -.
DR PhylomeDB; Q9SUQ3; -.
DR PRO; PR:Q9SUQ3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SUQ3; baseline and differential.
DR Genevisible; Q9SUQ3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Leucine-rich repeat; Membrane; Nucleotide-binding;
KW Phosphoprotein; Receptor; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..638
FT /note="Probable inactive receptor kinase At4g23740"
FT /id="PRO_0000324841"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 94..117
FT /note="LRR 1"
FT REPEAT 118..139
FT /note="LRR 2"
FT REPEAT 142..165
FT /note="LRR 3"
FT REPEAT 166..188
FT /note="LRR 4"
FT REPEAT 189..198
FT /note="LRR 5"
FT DOMAIN 337..608
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 612..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 343..351
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 365
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 339
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 360
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 416
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 419
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9LSI9"
FT MOD_RES 436
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 509
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 513
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
SQ SEQUENCE 638 AA; 70798 MW; 40F056B9AA68B7F6 CRC64;
MEALRIYLWS LCLSLCLIIY GANSDPLEDK RALLEFLTIM QPTRSLNWNE TSQVCNIWTG
VTCNQDGSRI IAVRLPGVGL NGQIPPNTIS RLSALRVLSL RSNLISGEFP KDFVELKDLA
FLYLQDNNLS GPLPLDFSVW KNLTSVNLSN NGFNGTIPSS LSRLKRIQSL NLANNTLSGD
IPDLSVLSSL QHIDLSNNYD LAGPIPDWLR RFPFSSYTGI DIIPPGGNYT LVTPPPPSEQ
THQKPSKARF LGLSETVFLL IVIAVSIVVI TALAFVLTVC YVRRKLRRGD GVISDNKLQK
KGGMSPEKFV SRMEDVNNRL SFFEGCNYSF DLEDLLRASA EVLGKGTFGT TYKAVLEDAT
SVAVKRLKDV AAGKRDFEQQ MEIIGGIKHE NVVELKAYYY SKDEKLMVYD YFSRGSVASL
LHGNRGENRI PLDWETRMKI AIGAAKGIAR IHKENNGKLV HGNIKSSNIF LNSESNGCVS
DLGLTAVMSP LAPPISRQAG YRAPEVTDTR KSSQLSDVYS FGVVLLELLT GKSPIHTTAG
DEIIHLVRWV HSVVREEWTA EVFDIELLRY TNIEEEMVEM LQIAMSCVVK AADQRPKMSD
LVRLIENVGN RRTSIEPEPE LKPKSENGAS ETSTPSEI
