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CAS1C_METHJ
ID   CAS1C_METHJ             Reviewed;         299 AA.
AC   Q2FNT7;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=CRISPR-associated endonuclease Cas1 3 {ECO:0000255|HAMAP-Rule:MF_01470};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01470};
GN   Name=cas1-3 {ECO:0000255|HAMAP-Rule:MF_01470}; OrderedLocusNames=Mhun_1375;
OS   Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS   JF-1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1;
RX   PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA   Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA   Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA   Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT   "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL   Stand. Genomic Sci. 11:2-2(2016).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat), is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as
CC       a dsDNA endonuclease. Involved in the integration of spacer DNA into
CC       the CRISPR cassette. {ECO:0000255|HAMAP-Rule:MF_01470}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01470};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01470};
CC   -!- SUBUNIT: Homodimer, forms a heterotetramer with a Cas2 homodimer.
CC       {ECO:0000255|HAMAP-Rule:MF_01470}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated endonuclease Cas1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01470}.
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DR   EMBL; CP000254; ABD41115.1; -; Genomic_DNA.
DR   RefSeq; WP_011448384.1; NC_007796.1.
DR   AlphaFoldDB; Q2FNT7; -.
DR   SMR; Q2FNT7; -.
DR   STRING; 323259.Mhun_1375; -.
DR   EnsemblBacteria; ABD41115; ABD41115; Mhun_1375.
DR   GeneID; 3923370; -.
DR   KEGG; mhu:Mhun_1375; -.
DR   eggNOG; arCOG01452; Archaea.
DR   HOGENOM; CLU_077904_1_0_2; -.
DR   OMA; IWVGEAG; -.
DR   OrthoDB; 42137at2157; -.
DR   Proteomes; UP000001941; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004520; F:endodeoxyribonuclease activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-UniRule.
DR   GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-UniRule.
DR   CDD; cd09719; Cas1_I-E; 1.
DR   Gene3D; 1.20.120.920; -; 1.
DR   Gene3D; 3.100.10.20; -; 1.
DR   HAMAP; MF_01470; Cas1; 1.
DR   InterPro; IPR033641; Cas1_I-E.
DR   InterPro; IPR002729; CRISPR-assoc_Cas1.
DR   InterPro; IPR042206; CRISPR-assoc_Cas1_C.
DR   InterPro; IPR019851; CRISPR-assoc_Cas1_ECOLI.
DR   InterPro; IPR042211; CRISPR-assoc_Cas1_N.
DR   Pfam; PF01867; Cas_Cas1; 1.
DR   TIGRFAMs; TIGR00287; cas1; 1.
DR   TIGRFAMs; TIGR03638; cas1_ECOLI; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; DNA-binding; Endonuclease; Hydrolase; Magnesium;
KW   Manganese; Metal-binding; Nuclease; Reference proteome.
FT   CHAIN           1..299
FT                   /note="CRISPR-associated endonuclease Cas1 3"
FT                   /id="PRO_0000417103"
FT   BINDING         143
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01470"
FT   BINDING         210
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01470"
FT   BINDING         223
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01470"
SQ   SEQUENCE   299 AA;  32507 MW;  6E2031E506918B9A CRC64;
     MTPTLPDIKP IPIKERSSVV FLGRGELDVI DGAFVLVDTN GIRMQIPVGG LASLMLEPGS
     RVSHAAVSLA SKVGCLLVFV GEGGVRLYSV GHPGGARSDR LLYQARLALD EVLRLKVVKK
     MFSLRFGEDF SDAYSVEQLR GLEGVRVREG YRKIARDTGV IWNGRRYDPH SWGSADLPNR
     CLSAATASLY GICEAAVLAA GYSPSIGFLH TGKPLSFVYD IADLFKFETV VPAAFKTAAL
     NPREPEREVR YACRDLFRET QLLKRIIPTI EEVLTAGGIS APAPPDWVVP PAIPVDEEG
 
 
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