CAS1C_RHORT
ID CAS1C_RHORT Reviewed; 371 AA.
AC Q2RV90;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=CRISPR-associated endonuclease Cas1 3 {ECO:0000255|HAMAP-Rule:MF_01470};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01470};
GN Name=cas1-3 {ECO:0000255|HAMAP-Rule:MF_01470}; OrderedLocusNames=Rru_A1154;
OS Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 /
OS NCIMB 8255 / S1).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Rhodospirillum.
OX NCBI_TaxID=269796;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX PubMed=21886856; DOI=10.4056/sigs.1804360;
RA Munk A.C., Copeland A., Lucas S., Lapidus A., Del Rio T.G., Barry K.,
RA Detter J.C., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N.C.,
RA Mavromatis K., Richardson P., Rohde M., Goeker M., Klenk H.P., Zhang Y.,
RA Roberts G.P., Reslewic S., Schwartz D.C.;
RT "Complete genome sequence of Rhodospirillum rubrum type strain (S1).";
RL Stand. Genomic Sci. 4:293-302(2011).
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat), is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain spacers, sequences complementary to
CC antecedent mobile elements, and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as
CC a dsDNA endonuclease. Involved in the integration of spacer DNA into
CC the CRISPR cassette. {ECO:0000255|HAMAP-Rule:MF_01470}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01470};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01470};
CC -!- SUBUNIT: Homodimer, forms a heterotetramer with a Cas2 homodimer.
CC {ECO:0000255|HAMAP-Rule:MF_01470}.
CC -!- SIMILARITY: Belongs to the CRISPR-associated endonuclease Cas1 family.
CC {ECO:0000255|HAMAP-Rule:MF_01470}.
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DR EMBL; CP000230; ABC21955.1; -; Genomic_DNA.
DR RefSeq; WP_011388909.1; NC_007643.1.
DR RefSeq; YP_426242.1; NC_007643.1.
DR AlphaFoldDB; Q2RV90; -.
DR SMR; Q2RV90; -.
DR STRING; 269796.Rru_A1154; -.
DR EnsemblBacteria; ABC21955; ABC21955; Rru_A1154.
DR KEGG; rru:Rru_A1154; -.
DR PATRIC; fig|269796.9.peg.1214; -.
DR eggNOG; COG1518; Bacteria.
DR HOGENOM; CLU_052779_1_1_5; -.
DR OMA; YYVGSFY; -.
DR OrthoDB; 1581397at2; -.
DR PhylomeDB; Q2RV90; -.
DR Proteomes; UP000001929; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-UniRule.
DR GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.120.920; -; 1.
DR Gene3D; 3.100.10.20; -; 1.
DR HAMAP; MF_01470; Cas1; 1.
DR InterPro; IPR002729; CRISPR-assoc_Cas1.
DR InterPro; IPR042206; CRISPR-assoc_Cas1_C.
DR InterPro; IPR042211; CRISPR-assoc_Cas1_N.
DR Pfam; PF01867; Cas_Cas1; 1.
DR TIGRFAMs; TIGR00287; cas1; 1.
PE 3: Inferred from homology;
KW Antiviral defense; DNA-binding; Endonuclease; Hydrolase; Magnesium;
KW Manganese; Metal-binding; Nuclease; Reference proteome.
FT CHAIN 1..371
FT /note="CRISPR-associated endonuclease Cas1 3"
FT /id="PRO_0000417085"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 189
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01470"
FT BINDING 254
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01470"
FT BINDING 269
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01470"
SQ SEQUENCE 371 AA; 39879 MW; C9A088F974608B18 CRC64;
MVGSGGTGAP PPRSSPMTTL YVTQPGSVVR SEGGSLTVWV ETEADDPGPN DSPVRRKRLA
SVEPHRLESL VLLGFTTITA NAMRLCMANK IAVSLLDGGG GLAARVVPPE ARSADLRLHQ
YALHLDPPER LIRARAVVTA KLRNAAAVLR GIRSNQASSA ALASAITQTE ASAEAAAAAV
SAESLLGIEG NGAHQYFAGL RTAFVGGIPF LGRAQRPPPD PANSLLSFGY VLLGNRLTGL
LEARGVDPCL GFFHDLRPGR PSLALDLLEE LRHPVVDRLA LRICNLRKIQ PQHFEPDAER
PGGVKLTVDG RKIFLEEWEG HLARPLREPG VAAEHRLDVH RLLQRQVDRL VSDLRGGEPY
RPFRFGTSRP G
