Y4399_DICDI
ID Y4399_DICDI Reviewed; 967 AA.
AC Q86AS0; Q554U3;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Probable helicase DDB_G0274399;
DE EC=3.6.4.-;
GN ORFNames=DDB_G0274399;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70092.1; -; Genomic_DNA.
DR RefSeq; XP_644230.1; XM_639138.1.
DR AlphaFoldDB; Q86AS0; -.
DR SMR; Q86AS0; -.
DR STRING; 44689.DDB0237968; -.
DR PaxDb; Q86AS0; -.
DR EnsemblProtists; EAL70092; EAL70092; DDB_G0274399.
DR GeneID; 8619659; -.
DR KEGG; ddi:DDB_G0274399; -.
DR dictyBase; DDB_G0274399; -.
DR eggNOG; KOG1801; Eukaryota.
DR HOGENOM; CLU_001666_11_2_1; -.
DR InParanoid; Q86AS0; -.
DR OMA; MVRCRQQ; -.
DR PhylomeDB; Q86AS0; -.
DR PRO; PR:Q86AS0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0001147; F:transcription termination site sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10887; PTHR10887; 3.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..967
FT /note="Probable helicase DDB_G0274399"
FT /id="PRO_0000363160"
FT REGION 161..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 890..949
FT /evidence="ECO:0000255"
FT COMPBIAS 168..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..917
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 357..364
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 967 AA; 109237 MW; DD1CA69BDE696AA2 CRC64;
MTTIVAPPIK SITSIDNDDN VDGVIEKSVK KPVSLTFDQI IDRFYKHILT WDASDLSPKE
KELKPVKVSF NNEEDYITTY EPLLFEECRA QLERSIEEGE KDDTSEPTLS RVRYISEVND
FLVVGLVMAE NVNIFQFHDN DLIMISLHHP LIVFGMDEDE EMTDDEDTAP TSAATHVGAP
TKSTTTTTTT TTTTTTTTTT ATTNIIDDPN KTTEDIKKKK KVIPPSKTPI TEQNRTLHLI
GTVEHLDNGG IKVKFYVKGI KGDRARQVSL LLRYEIDWWT TKLCNLSTLQ REFAALYQCS
QSNFMKTLMM RDDDGEDGIV MKIPPLLHDQ FSSTYNDSQL NALTSALEGN AITLIQGPPG
TGKTHVILGL ISVLLHSTIV PKVKSGGNNL GDHLLKDREL SMAEKRDLWN ISQPWFNKEF
PHIRDNYELI DYDFEERDQK RKRDLWRKLR DTGSVKGGST KRRILLCAPS NGAVDEIVSR
LIRDGLLNAD GRKYNPNLVR VGPGSHSDVE SVSLDYMVRC RQQLMNSNSA IPSSSASTAA
ATSGSSRSTQ DTSSIRTLVL DEADIVATTL SFSGASLLTK MAGGFDIVII DEAAQAVETS
TLIPIQHGCK KVVLVGDPKQ LPATIISPLA IKYKYDQSLF QRLQEKNSPH MLTTQYRMHS
LIRAFPSRHF YQDLLLDGPN IPSRATHYHS NPFFGPLVFY DLSWSTETKP GGGSVFNEHE
CKMAMYLFQL FTKVYPDEDF ASRIGIISPY RQQVLALREI FKNYPGISID TVDGFQGRER
EIIIFSCVRA PVEEGAGIGF LSDVRRMNVA LTRPRSSLLI LGNTKALSIN KDWNELIQHT
QNNQQLIPVT KDQPLEIIIP TFTTRELFTE LSEKGQQIVI PKPRTEEEIN LQKQKDIEKR
KKQHKRQKQK SKENDKKKQL KKRKELNNND NNNNNKESSN KEVQEITNAE VVKDTEINNT
KRARTRR
