Y442_HAEIN
ID Y442_HAEIN Reviewed; 109 AA.
AC P44711;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Nucleoid-associated protein HI_0442 {ECO:0000255|HAMAP-Rule:MF_00274};
GN OrderedLocusNames=HI_0442;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=10675023;
RX DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA Fountoulakis M.;
RT "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL Electrophoresis 21:411-429(2000).
RN [3]
RP DNA-BINDING, AND SUBUNIT.
RX PubMed=19594923; DOI=10.1186/1471-2180-9-137;
RA Cooley A.E., Riley S.P., Kral K., Miller M.C., DeMoll E., Fried M.G.,
RA Stevenson B.;
RT "DNA-binding by Haemophilus influenzae and Escherichia coli YbaB, members
RT of a widely-distributed bacterial protein family.";
RL BMC Microbiol. 9:137-137(2009).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), AND SUBUNIT.
RX PubMed=12486730; DOI=10.1002/prot.10297;
RA Lim K., Tempczyk A., Parsons J.F., Bonander N., Toedt J., Kelman Z.,
RA Howard A., Eisenstein E., Herzberg O.;
RT "Crystal structure of YbaB from Haemophilus influenzae (HI0442), a protein
RT of unknown function coexpressed with the recombinational DNA repair protein
RT RecR.";
RL Proteins 50:375-379(2003).
CC -!- FUNCTION: Binds to DNA and alters its conformation. May be involved in
CC regulation of gene expression, nucleoid organization and DNA
CC protection. {ECO:0000255|HAMAP-Rule:MF_00274}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00274,
CC ECO:0000269|PubMed:12486730, ECO:0000269|PubMed:19594923}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_00274}.
CC -!- SIMILARITY: Belongs to the YbaB/EbfC family. {ECO:0000255|HAMAP-
CC Rule:MF_00274}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC22101.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L42023; AAC22101.1; ALT_INIT; Genomic_DNA.
DR PIR; G64152; G64152.
DR RefSeq; NP_438603.2; NC_000907.1.
DR RefSeq; WP_005629464.1; NC_000907.1.
DR PDB; 1J8B; X-ray; 1.75 A; A=1-109.
DR PDBsum; 1J8B; -.
DR AlphaFoldDB; P44711; -.
DR SMR; P44711; -.
DR STRING; 71421.HI_0442; -.
DR EnsemblBacteria; AAC22101; AAC22101; HI_0442.
DR KEGG; hin:HI_0442; -.
DR PATRIC; fig|71421.8.peg.462; -.
DR eggNOG; COG0718; Bacteria.
DR HOGENOM; CLU_140930_0_0_6; -.
DR PhylomeDB; P44711; -.
DR BioCyc; HINF71421:G1GJ1-457-MON; -.
DR EvolutionaryTrace; P44711; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0043590; C:bacterial nucleoid; IEA:UniProtKB-UniRule.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR Gene3D; 3.30.1310.10; -; 1.
DR HAMAP; MF_00274; DNA_YbaB_EbfC; 1.
DR InterPro; IPR036894; YbaB-like_sf.
DR InterPro; IPR004401; YbaB/EbfC.
DR PANTHER; PTHR33449; PTHR33449; 1.
DR Pfam; PF02575; YbaB_DNA_bd; 1.
DR PIRSF; PIRSF004555; UCP004555; 1.
DR SUPFAM; SSF82607; SSF82607; 1.
DR TIGRFAMs; TIGR00103; DNA_YbaB_EbfC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; Reference proteome.
FT CHAIN 1..109
FT /note="Nucleoid-associated protein HI_0442"
FT /id="PRO_0000170397"
FT HELIX 10..28
FT /evidence="ECO:0007829|PDB:1J8B"
FT STRAND 31..37
FT /evidence="ECO:0007829|PDB:1J8B"
FT TURN 38..41
FT /evidence="ECO:0007829|PDB:1J8B"
FT STRAND 42..47
FT /evidence="ECO:0007829|PDB:1J8B"
FT STRAND 52..57
FT /evidence="ECO:0007829|PDB:1J8B"
FT HELIX 59..63
FT /evidence="ECO:0007829|PDB:1J8B"
FT HELIX 66..95
FT /evidence="ECO:0007829|PDB:1J8B"
SQ SEQUENCE 109 AA; 11969 MW; 4C6D43D6A9E51361 CRC64;
MFGKGGLGGL MKQAQQMQEK MQKMQEEIAQ LEVTGESGAG LVKITINGAH NCRRIDIDPS
LMEDDKEMLE DLIAAAFNDA VRRAEELQKE KMASVTAGMP LPPGMKFPF
