位置:首页 > 蛋白库 > CAS1_CRYNB
CAS1_CRYNB
ID   CAS1_CRYNB              Reviewed;         960 AA.
AC   P0CM57; Q55HH1; Q5K709; Q8X227;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Probable O-acetyltransferase CAS1;
DE            EC=2.3.1.-;
DE   AltName: Full=Capsule synthesis protein 1;
GN   Name=CAS1; OrderedLocusNames=CNBN1490;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Probable O-acetyltransferase required for the O-acetylation
CC       of the capsular glucoronoxylmannans (GXM) involved in virulence.
CC       {ECO:0000250|UniProtKB:P0CM56}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PC-esterase family. CASD1 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAEY01000066; EAL17322.1; -; Genomic_DNA.
DR   RefSeq; XP_771969.1; XM_766876.1.
DR   AlphaFoldDB; P0CM57; -.
DR   EnsemblFungi; AAW47111; AAW47111; CNN01530.
DR   EnsemblFungi; EAL17322; EAL17322; CNBN1490.
DR   GeneID; 4939760; -.
DR   KEGG; cnb:CNBN1490; -.
DR   VEuPathDB; FungiDB:CNBN1490; -.
DR   HOGENOM; CLU_008003_0_1_1; -.
DR   Proteomes; UP000001435; Chromosome 14.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   InterPro; IPR012419; Cas1_AcylTrans_dom.
DR   Pfam; PF07779; Cas1_AcylT; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Oxidoreductase; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..960
FT                   /note="Probable O-acetyltransferase CAS1"
FT                   /id="PRO_0000410030"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        501..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        525..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        555..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        579..599
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        609..629
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        655..675
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        692..712
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        715..735
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        940..960
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        115
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q96PB1"
FT   ACT_SITE        350
FT                   /evidence="ECO:0000250|UniProtKB:Q96PB1"
FT   ACT_SITE        353
FT                   /evidence="ECO:0000250|UniProtKB:Q96PB1"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        830
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   960 AA;  107504 MW;  6AA05D5FCD2650F7 CRC64;
     MPNSSKPRSQ ASAAKLNPLW YTYACATLVA AVVLGNILRW AFLELPDSYH CSALLNTGKW
     LDPGTWTNWQ PEGCFQLPLS AQSWQKCLAS PTVNTHQALH SSYYDKRTAL FVGDSTVRQL
     YFAAARKVGK TSKAWELEGE KHTDRSLLVS DPLGGPSLEL EFWWDPYLNS SKTIGLLSGQ
     SSVPSSLLVM GSGLWYLRNP SSGGLASWGA MIYDTFELVK KNQGSPQTAL INPWDNMLLG
     PGITLPGLLP NQPPKFVDHS REVEARSLFS RASSISHRPT DFSISDAIVF LPISTPVREK
     LSPSRAETIF HTDVEAMNAD LYARLTHPDP PPVVIPSVLN QLLVDDETED GLHFSDKIMN
     KQAELLLSWR CNDVMRHEGA TGTCCKRYDW VTPIQGLILA VLILWAPLGT FITPRLPPNS
     PILDYLPATS IAPALSTFGL AMGYLFLADR THVFQKEQKD YDAVIFGMIT LAAFVAGLLT
     IKNSGKDLGF LNRDITDEWK GWMQIAILIY HFFGASKISG IYNPIRVLVA SYLFMTGYGH
     FFFYYKKADF GFQRVVMVLV RLNLLSVVLP YTMNTDYAFY YFAPLVSWWY LIIYATMAIG
     SKYNDRPAFL LTKLFTCAGL VTLFMHFPWL MEDVFKVLNT VFNIQWSAKE WSFRVTLDLF
     IVWVGMLCAY GFVKFNEHQI SDRPWFPVMR TATLVGSVLG MIWYFWFELH LASKFVYNEY
     HAVVCIVPIM SFVFLRNASP VLRSSTSKIF CFIGQCSLET FILQFHGWLA SDTKAILLAV
     PSTQWRPVNL VISTICFIWL SYRVSGATGE ITEWLVGKKK ALPLPATSAN SSTSPGRQAT
     SPTLTSASAM QAVVVGPQDG AKGGIPESIP MMNQADKDIG GLTPMEDETL ERRDSWPTWM
     ASTAASLTGR TVEGYAPLTR RWKDQTVLSV IQNLGDLMKK HNSVKIAVIL LGLWALNWIY
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024