ID   Y4435_MYCA1             Reviewed;         303 AA.
AC   A0QKY2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAV_4435;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAV_4435;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000479; ABK67851.1; -; Genomic_DNA.
DR   RefSeq; WP_009979041.1; NC_008595.1.
DR   AlphaFoldDB; A0QKY2; -.
DR   SMR; A0QKY2; -.
DR   EnsemblBacteria; ABK67851; ABK67851; MAV_4435.
DR   KEGG; mav:MAV_4435; -.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; QDSWDLA; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000001574; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..303
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAV_4435"
FT                   /id="PRO_0000361107"
FT   BINDING         129
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         158..159
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  33331 MW;  E5ACBD2DE9A826BD CRC64;
     MTRTDQDSWD LASSVGATAT MVAAARALAS TGERPIINDP FAAPLVRAVG LDFFRRLVDG
     EVAPADPQRG ERDLQLETDS IAVRTRFFDD FFTGAARDGI RQSVILAAGL DARAYRLDWP
     AGAVVYEVDQ PKVVEFKTNT MAALDARPAA QLRTVSIDLR EDWPEALRAN GFDVTQATSW
     SAEGLLMYLP PEAQDRLFDN ITALSAPGSR LATEYHPDAT GTTMAQRAQE FNDRWARVGC
     DIDLSGLFFD GERSNVVEYL TGRGWRVSAR PRRDLFDDYG LAYPEDDETA QFPNIVAVSA
     ELG