ID   Y449_METJA              Reviewed;         283 AA.
AC   Q57891;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Uncharacterized transporter MJ0449;
GN   OrderedLocusNames=MJ0449;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98438.1; -; Genomic_DNA.
DR   PIR; A64356; A64356.
DR   RefSeq; WP_010869948.1; NC_000909.1.
DR   AlphaFoldDB; Q57891; -.
DR   SMR; Q57891; -.
DR   STRING; 243232.MJ_0449; -.
DR   EnsemblBacteria; AAB98438; AAB98438; MJ_0449.
DR   GeneID; 1451309; -.
DR   KEGG; mja:MJ_0449; -.
DR   eggNOG; arCOG01474; Archaea.
DR   HOGENOM; CLU_013430_3_3_2; -.
DR   InParanoid; Q57891; -.
DR   OMA; IEMHLIV; -.
DR   OrthoDB; 110591at2157; -.
DR   PhylomeDB; Q57891; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   Gene3D; 3.30.70.1350; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027470; Cation_efflux_CTD.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   Pfam; PF16916; ZT_dimer; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..283
FT                   /note="Uncharacterized transporter MJ0449"
FT                   /id="PRO_0000206139"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   283 AA;  31286 MW;  4F9128C4222365FE CRC64;
     MREVEKPLIL SIVGNILLGL IKIIIGYVYS SISLISDGIH SLSDVITSII GIIGVKIASK
     PPDESHPYGH SRFECLFSFF IGLALFFTAY EIGKFAVERI IYGEVIEVNA IMVGVAILSI
     VVKELMTRYS LFVGKKLNSQ VLIADAYHHR SDALSSVVVL VGLLLQKFGI YYGDAIAGII
     VALMIAKVAF DICLTNIDYL TGRAPPKKFF ELIEKEALNV DKVIGVHDIK AHYVGPRIHV
     ELHVEVPSNI SAKEMHDIEV AVKNRLESLE NVERAYVHVD IVD