ID   Y449_TREPA              Reviewed;         196 AA.
AC   O83463;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Uncharacterized lipoprotein TP_0449;
DE   Flags: Precursor;
GN   OrderedLocusNames=TP_0449;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
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DR   EMBL; AE000520; AAC65437.1; -; Genomic_DNA.
DR   PIR; A71325; A71325.
DR   RefSeq; WP_010881897.1; NC_021490.2.
DR   AlphaFoldDB; O83463; -.
DR   SMR; O83463; -.
DR   IntAct; O83463; 51.
DR   STRING; 243276.TPANIC_0449; -.
DR   EnsemblBacteria; AAC65437; AAC65437; TP_0449.
DR   GeneID; 57878973; -.
DR   KEGG; tpa:TP_0449; -.
DR   eggNOG; COG0457; Bacteria.
DR   HOGENOM; CLU_1389674_0_0_12; -.
DR   OMA; PGENERI; -.
DR   OrthoDB; 1906165at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..196
FT                   /note="Uncharacterized lipoprotein TP_0449"
FT                   /id="PRO_0000014249"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   196 AA;  22570 MW;  67DE09899A6FF70B CRC64;
     MNGKQCFCFF LFHLFYTGLF ACGKPESSLA PEYFDLAHAY VQLHRYDEAR DYYMRAARDP
     AYYHAAQYNF ARVCGLQNDW KTAVHALQPL YDADSANATI AAAYAYALLS FGETARALLL
     YQQLYERDQK NTQRILEYAN VLVHAKKYIQ AVEFLRQKKS LLSEAEDVRV LQSIVRKLKD
     SVPPHLIADF VSTDDL