ID   Y4527_DICDI             Reviewed;         475 AA.
AC   Q869Q0; Q555J0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=COBW domain-containing protein DDB_G0274527;
GN   ORFNames=DDB_G0274527;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. CobW
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70156.1; -; Genomic_DNA.
DR   RefSeq; XP_644077.1; XM_638985.1.
DR   AlphaFoldDB; Q869Q0; -.
DR   SMR; Q869Q0; -.
DR   STRING; 44689.DDB0238044; -.
DR   PaxDb; Q869Q0; -.
DR   PRIDE; Q869Q0; -.
DR   EnsemblProtists; EAL70156; EAL70156; DDB_G0274527.
DR   GeneID; 8619506; -.
DR   KEGG; ddi:DDB_G0274527; -.
DR   dictyBase; DDB_G0274527; -.
DR   eggNOG; KOG2743; Eukaryota.
DR   HOGENOM; CLU_017452_2_0_1; -.
DR   InParanoid; Q869Q0; -.
DR   OMA; WSQAGPN; -.
DR   PhylomeDB; Q869Q0; -.
DR   PRO; PR:Q869Q0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1220.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011629; Cbl_biosynth_CobW-like_C.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..475
FT                   /note="COBW domain-containing protein DDB_G0274527"
FT                   /id="PRO_0000367827"
FT   DOMAIN          302..420
FT                   /note="CobW C-terminal"
FT   REGION          445..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          440..467
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        445..462
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         50..57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         119..123
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         229..232
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   475 AA;  54301 MW;  5AA336F8C72EE00F CRC64;
     MVNKTSTNNN KEPRRMKKHY LKSNASNLKK TLHKIKVRGF EKLPVSVLSG FLGSGKTTLL
     NYILNSNHGL KIAVIVNDMS EVNIDSKLIL ENEFKITRTK ATEKQVEAVV EMSNGCICCT
     MREDLLVEVT KLAKEKRFDY LIIESSGISE PLPIAETFTF EIDGSIENLK DYTKLDTMVT
     VVDCSTWLEQ YQSGESLKDK DMQATDQDER SLVDLLLDQV EFSNVILLNK CDLVSEERVK
     TIEGLIKHIN PEARLLRSTN SVVPLKEILN TGLFDFKKAS EHPGWLKELR GTHVPETIEY
     GIKSFIYKAR RPFNSERLSN VIEKGSAVFG GVLRSKGFSW IASTPELIGM WNLAGVQMTI
     LNYGYWLADL KPHEYPNLDL QKEIKKNWSE PFGDRRQELV FIGGNTMNQS LIESELNNCL
     LTDAELLLGK DIWRTWIDPI QLDEELEEEE LEEEEEEGEY KDEIEMKVDG SKFKK