ID   Y452_BUCAI              Reviewed;         305 AA.
AC   P57527;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Uncharacterized MscS family protein BU452;
GN   OrderedLocusNames=BU452;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family. {ECO:0000305}.
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DR   EMBL; BA000003; BAB13150.1; -; Genomic_DNA.
DR   RefSeq; NP_240264.2; NC_002528.1.
DR   AlphaFoldDB; P57527; -.
DR   SMR; P57527; -.
DR   STRING; 107806.10039116; -.
DR   EnsemblBacteria; BAB13150; BAB13150; BAB13150.
DR   KEGG; buc:BU452; -.
DR   PATRIC; fig|107806.10.peg.462; -.
DR   eggNOG; COG0668; Bacteria.
DR   HOGENOM; CLU_037945_1_1_6; -.
DR   OMA; GMQDTLT; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008381; F:mechanosensitive ion channel activity; IEA:InterPro.
DR   Gene3D; 2.30.30.60; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR045275; MscS_archaea/bacteria_type.
DR   InterPro; IPR006685; MscS_channel.
DR   InterPro; IPR011066; MscS_channel_C.
DR   InterPro; IPR006686; MscS_channel_CS.
DR   InterPro; IPR011014; MscS_channel_TM-2.
DR   InterPro; IPR023408; MscS_dom_sf.
DR   InterPro; IPR008910; TM_helix.
DR   PANTHER; PTHR30221; PTHR30221; 1.
DR   Pfam; PF00924; MS_channel; 1.
DR   Pfam; PF05552; TM_helix; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   SUPFAM; SSF82689; SSF82689; 1.
DR   SUPFAM; SSF82861; SSF82861; 1.
DR   PROSITE; PS01246; UPF0003; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..305
FT                   /note="Uncharacterized MscS family protein BU452"
FT                   /id="PRO_0000110246"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  34129 MW;  6F99B52D3EB9AA56 CRC64;
     MLFIKIEIIA KTLLIINKKY TEIKMDELNV VNNINHAGTW LIRNQELLLR YTINLTSAII
     ILVVGMFISK IISNGANQVL ITRNIDATIA GFLSALMRYI IITFTFIAAL GRIGVQTTSV
     IAILGAAGMA IGLALQGSLS NFAAGVLLVT LRPLKTEEYV DLGSVSGTVL NIHIFYTTLR
     TLDGKIVVVP NNKIISGNII NYSREPARRN EFIISVSYNS DIDLVIKILR SVIEKEERVI
     KDKDIIVGLS ELAPSSLNFI VRCWSKNHDL NTVYWDLMAK FKKELDKNNI NIPFPQLDVH
     VYKKK