ID   Y456_TREPA              Reviewed;         438 AA.
AC   O83469;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Uncharacterized lipoprotein TP_0456;
DE   Flags: Precursor;
GN   OrderedLocusNames=TP_0456;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
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DR   EMBL; AE000520; AAC65445.1; -; Genomic_DNA.
DR   PIR; A71323; A71323.
DR   RefSeq; WP_010881905.1; NC_021490.2.
DR   AlphaFoldDB; O83469; -.
DR   STRING; 243276.TPANIC_0456; -.
DR   EnsemblBacteria; AAC65445; AAC65445; TP_0456.
DR   GeneID; 57878980; -.
DR   KEGG; tpa:TP_0456; -.
DR   eggNOG; ENOG5032P03; Bacteria.
DR   HOGENOM; CLU_064740_0_0_12; -.
DR   OMA; CANKEAE; -.
DR   OrthoDB; 731392at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           21..438
FT                   /note="Uncharacterized lipoprotein TP_0456"
FT                   /id="PRO_0000014250"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   438 AA;  47352 MW;  7CA919FBF0D651D6 CRC64;
     MNTRLALVLC AVGSGVLSFS CARTAEPTPA ASTHVPVTTA GALSVTPPSS TDRWYQFSRT
     DGRVHLRACP APSQPSAPEH FVPWTEAVRL SAVDAQQELL LINRAGVLPA TQLARMQTAP
     VPRKAPSTPA AETTSLTLTP PALLATQSAE GFYSEPIPNS SPHPCQGTGA VFVRLYTDPL
     FTTSPQDSAA PFLVRYDVRT ARWTSVAYTR ALGLPRNAQC TALTHTRGTW YASFKSSEAE
     RVSFAYFSFP SLSSLENLGP TQRREHPIGG KVQVPRPISA AAFRAACTPQ RLHLPTASTS
     SDHHSDLHEL LVHRLLARVP LSPLYLSARS PCWASDRSFL KTAHRTADER AHHANALIFH
     PPRARLSAAL LTDSGHLYFV REDGSEGHAR LSALPPQFVY TSFTLSGPSL IAGWEEQDFF
     QVGSTGLLCT EVESLTGT