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Y4613_DICDI
ID   Y4613_DICDI             Reviewed;         831 AA.
AC   Q554L2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Probable inactive serine/threonine-protein kinase DDB_G0274613;
GN   ORFNames=DDB_G0274613;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70199.1; -; Genomic_DNA.
DR   RefSeq; XP_644311.1; XM_639219.1.
DR   AlphaFoldDB; Q554L2; -.
DR   STRING; 44689.DDB0230051; -.
DR   PaxDb; Q554L2; -.
DR   PRIDE; Q554L2; -.
DR   EnsemblProtists; EAL70199; EAL70199; DDB_G0274613.
DR   GeneID; 8619739; -.
DR   KEGG; ddi:DDB_G0274613; -.
DR   dictyBase; DDB_G0274613; -.
DR   eggNOG; KOG0660; Eukaryota.
DR   HOGENOM; CLU_341439_0_0_1; -.
DR   InParanoid; Q554L2; -.
DR   OMA; FEFLECS; -.
DR   Reactome; R-DDI-193648; NRAGE signals death through JNK.
DR   Reactome; R-DDI-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-DDI-2871796; FCERI mediated MAPK activation.
DR   Reactome; R-DDI-4086398; Ca2+ pathway.
DR   Reactome; R-DDI-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
DR   Reactome; R-DDI-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-DDI-9007892; Interleukin-38 signaling.
DR   PRO; PR:Q554L2; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..831
FT                   /note="Probable inactive serine/threonine-protein kinase
FT                   DDB_G0274613"
FT                   /id="PRO_0000362055"
FT   DOMAIN          414..787
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ZN_FING         9..63
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          657..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          83..348
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   831 AA;  95386 MW;  72EB021604771E07 CRC64;
     MDPFEFLECS ICSEEVIDFA AIFSSNKKFG DKACKHNFCV SCLTYLMEYN TRNKKALCCP
     ICREEFDGFI QNKTSSDLLK QARKLSSAQI FLKNENSKLN EEINLIKNER ENEAIQYRDR
     IKQLEDSKSK QVQESTNIKS RIKEMENEIQ SLEQARLLDL QNNQSKFDTQ QQQILTLTQS
     YRESQSNYND SNLRANELNN QIQKLYREIE GFKQHAQQQD NYIKDIDSEK QLLQQQLSTI
     EQSYDRKQSD LLNNTRLKDL QIAKLSDANQ QLGTSLSKIE AECEHFKKLY KEIQEDANGG
     YQKNKNLESA IASLNIELSR SKSVIDSLNT NKRTLEKELE EMKLLYQFGR GTSISSSIAP
     PTIINTANKI TNSSYNLINN SIGYFMGSKN YLNDITKPYK GFKIEEKRGN KTSQIHKVSI
     GNGCGHFVIK LIPTVSGTNV GNSYSKFIYN SIYSSTLAES EILLFREAML LYKLNHNNIL
     KLESITKDES SGKYYSVLSP FVPKDLEFIL AENSQNFGGL GKISPTTLTF SDIKYIVYQL
     ISVVHYLHTQ DLVHRDLKPT SILLFDDYQI KLCSFGNAIS VFTNFGNSIT QPTYSNPSSY
     SYLSPEYICS VLDKENHSKL SNEIDWKAFD MWSIGCIFLE LIYKKKLFNN LNLDNNNNNN
     NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNIES NFNNVNNSQQ QQLYSVLNNI
     STYKESAPKN GNLYFKENHN IIIKSKVERD FNGANLPTDA YNLLCALLSF NPTTRIKANQ
     AAFHKFFKDE PYYIHDSASV SPNKLEDLSS LLTDRNIKQF LKEKCSNLIQ V
 
 
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