ID   Y461_MYCGE              Reviewed;         425 AA.
AC   P47699;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2018, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Uncharacterized protein MG461;
GN   OrderedLocusNames=MG461;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   SEQUENCE REVISION TO 214, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=16407165; DOI=10.1073/pnas.0510013103;
RA   Glass J.I., Assad-Garcia N., Alperovich N., Yooseph S., Lewis M.R.,
RA   Maruf M., Hutchison C.A. III, Smith H.O., Venter J.C.;
RT   "Essential genes of a minimal bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:425-430(2006).
CC   -!- DISRUPTION PHENOTYPE: Probably essential, it was not disrupted in a
CC       global transposon mutagenesis study. {ECO:0000269|PubMed:16407165}.
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DR   EMBL; L43967; AAC72481.2; -; Genomic_DNA.
DR   PIR; I64250; I64250.
DR   RefSeq; WP_010869489.1; NC_000908.2.
DR   AlphaFoldDB; P47699; -.
DR   SMR; P47699; -.
DR   STRING; 243273.MG_461; -.
DR   EnsemblBacteria; AAC72481; AAC72481; MG_461.
DR   KEGG; mge:MG_461; -.
DR   eggNOG; COG1078; Bacteria.
DR   HOGENOM; CLU_026821_0_0_14; -.
DR   OMA; ITEKKAY; -.
DR   OrthoDB; 370035at2; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0008832; F:dGTPase activity; IBA:GO_Central.
DR   GO; GO:0006203; P:dGTP catabolic process; IBA:GO_Central.
DR   CDD; cd00077; HDc; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS51831; HD; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..425
FT                   /note="Uncharacterized protein MG461"
FT                   /id="PRO_0000210629"
FT   DOMAIN          55..181
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   425 AA;  50366 MW;  81410DBE304B30B9 CRC64;
     MQQTFFKDPI LGEIIFDENT KWMYELVNTK AFQRLRNIKQ LGINFHFYPS GVHTRYAHSL
     GVYELIRRIL NSSAFLNIDQ IKKQTVLVAG LLHDLGHGPH SHAFEIYFAK NPDFKKQLFI
     HEKVTSMLVN SEPIVSILKA NKIDPNLIGA LIDENQNIQP INWWMRQLIS SDLDTDRMDY
     LLRDAYFTGT SHSLVDYQSI INGMECVDNQ GTYEIVFQEK CLPFIENFLI TRHHMYQSIY
     SDGRSIATEL NLWFVFQRIK ALIEEDNFNF HNFKNVESVI KPLLKNQLFK KSLLTCFVKL
     DDYVFHSFLV NTFETTKDAI LKTLLDSYLN TLKFQVKFYE SCEKRDLDFE LKVKEYQTPS
     YFITKFNNQF KGFYEGWNKH KNELKIKTSQ NKIKNLSEIS MLVKRSNELF FENSFYRWAN
     VFYQN