ID   Y4628_STRCO             Reviewed;         269 AA.
AC   Q04296; Q04335; Q9F2T4;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2002, sequence version 3.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator SCO4628;
GN   OrderedLocusNames=SCO4628; ORFNames=SCD39.28;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2770697; DOI=10.1007/bf02464900;
RA   Grant S.R., Lee S.C., Kendall K., Cohen S.N.;
RT   "Identification and characterization of a locus inhibiting extrachromosomal
RT   maintenance of the Streptomyces plasmid SLP1.";
RL   Mol. Gen. Genet. 217:324-331(1989).
RN   [2]
RP   SEQUENCE REVISION.
RA   Shiffman D., Cohen S.N.;
RL   Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: The imp locus inhibits the extrachromosomal maintenance of
CC       the Streptomyces plasmid SLP1.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA33875.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X15866; CAA33875.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL939120; CAC08281.1; -; Genomic_DNA.
DR   PIR; JQ0322; JQ0322.
DR   PIR; JQ0323; JQ0323.
DR   RefSeq; NP_628790.1; NC_003888.3.
DR   RefSeq; WP_011029777.1; NZ_VNID01000028.1.
DR   AlphaFoldDB; Q04296; -.
DR   SMR; Q04296; -.
DR   STRING; 100226.SCO4628; -.
DR   PRIDE; Q04296; -.
DR   GeneID; 1100068; -.
DR   KEGG; sco:SCO4628; -.
DR   PATRIC; fig|100226.15.peg.4701; -.
DR   eggNOG; COG2188; Bacteria.
DR   HOGENOM; CLU_063236_8_1_11; -.
DR   OMA; APKWREL; -.
DR   PhylomeDB; Q04296; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..269
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   SCO4628"
FT                   /id="PRO_0000050704"
FT   DOMAIN          5..73
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   269 AA;  29695 MW;  10341B9BE118E191 CRC64;
     MAPKAPKWRE LADRFAEQIR TGDYGPGEQL PQIRDLVEAG EGSKETVHRA YKALETEGLV
     AMSRGHGTVV RRKAPLKRLG IGRYDKAKWR DGDEVAFIAD RVASGRSYRR NEQTQTVSRV
     KASAAVATAL GLPEGADVYA RARLVKEGTQ PTHTLTSYYR PEHVEGTRIV DPTPGPAGRG
     GGFRVLYDAG YEIDHMTEEI FARVPSAEEA QLLQLAPGEW VVELHRTTRT VDGTVVEFAI
     GVHAGTRFAW SYDFKVPDSA MTEAEDESK