ID   Y462_TREPA              Reviewed;         392 AA.
AC   O83475; O83476;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Uncharacterized lipoprotein TP_0462/TP_0463;
DE   Flags: Precursor;
GN   OrderedLocusNames=TP_0462/TP_0463;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the TP013X lipoprotein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC65456.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
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DR   EMBL; AE000520; AAC65455.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE000520; AAC65456.1; ALT_FRAME; Genomic_DNA.
DR   PIR; A71321; A71321.
DR   PIR; H71320; H71320.
DR   AlphaFoldDB; O83475; -.
DR   IntAct; O83475; 22.
DR   STRING; 243276.TPANIC_0462; -.
DR   EnsemblBacteria; AAC65455; AAC65455; TP_0462.
DR   EnsemblBacteria; AAC65456; AAC65456; TP_0463.
DR   KEGG; tpa:TP_0462; -.
DR   KEGG; tpa:TP_0463; -.
DR   HOGENOM; CLU_056007_0_0_12; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           20..392
FT                   /note="Uncharacterized lipoprotein TP_0462/TP_0463"
FT                   /id="PRO_0000018068"
FT   REGION          148..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           20
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           20
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   392 AA;  40261 MW;  F2689260172607AE CRC64;
     MRRIVCPPVL FLSASLLTGC DFSGIFASIQ SEVPLKIPSI RGVVTGLVKC NNKLYACAGQ
     LWEKDASKSE GKWTAVNFLP GKKITSIVSK GACVYACVSG EGVYTYTSNG AGRTGGTTTP
     STVLGKTNGA IRIGGSDNPF LQMPCELSSG SSGGGGGGSG SSSDGGIKNG SDENVLGSGT
     GYVVTTKAVY TKSNSSGTSC TYTKDGTFTA TTSPILGCTS DGKGCFYVLD GTDVHCRTVQ
     ASGGGNGAHC AVASGSATSC KVAHTVTNPL CIAHVKNGQT EFLLIGGSQG YKEIKLETGS
     GSGTGCLKAE NVRGPEQWGE DSVTPKDRVS QYEGTIGRFA ISDIYTVEST SGAGGTNGGT
     NKPDVYVVVG DSQDGYTGLW RFDAQKKEWN RE