Y4695_DICDI
ID Y4695_DICDI Reviewed; 389 AA.
AC Q555L8; Q8MML2; Q8T177;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=SH3 and F-BAR domain-containing protein DDB_G0274695;
GN ORFNames=DDB_G0274695;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AC123513; AAM44380.1; -; Genomic_DNA.
DR EMBL; AAFI02000012; EAL70240.1; -; Genomic_DNA.
DR RefSeq; XP_644048.1; XM_638956.1.
DR AlphaFoldDB; Q555L8; -.
DR SMR; Q555L8; -.
DR STRING; 44689.DDB0266841; -.
DR PaxDb; Q555L8; -.
DR EnsemblProtists; EAL70240; EAL70240; DDB_G0274695.
DR GeneID; 8619478; -.
DR KEGG; ddi:DDB_G0274695; -.
DR dictyBase; DDB_G0274695; slp.
DR eggNOG; KOG2398; Eukaryota.
DR HOGENOM; CLU_710646_0_0_1; -.
DR InParanoid; Q555L8; -.
DR OMA; MEAMAHV; -.
DR PhylomeDB; Q555L8; -.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q555L8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031982; C:vesicle; IDA:dictyBase.
DR GO; GO:0008017; F:microtubule binding; IDA:dictyBase.
DR GO; GO:0030041; P:actin filament polymerization; IGI:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IGI:dictyBase.
DR GO; GO:0016050; P:vesicle organization; IGI:dictyBase.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil; Reference proteome; SH3 domain.
FT CHAIN 1..389
FT /note="SH3 and F-BAR domain-containing protein
FT DDB_G0274695"
FT /id="PRO_0000384437"
FT DOMAIN 3..258
FT /note="F-BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01077"
FT DOMAIN 332..389
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 300..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 119..192
FT /evidence="ECO:0000255"
FT CONFLICT 204
FT /note="S -> F (in Ref. 1; AAM44380)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="T -> P (in Ref. 1; AAM44380)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="T -> P (in Ref. 1; AAM44380)"
FT /evidence="ECO:0000305"
FT CONFLICT 335
FT /note="K -> N (in Ref. 1; AAM44380)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 389 AA; 44221 MW; 8E01112F246EDA86 CRC64;
MSEQFKDNFW GPNGFETIEK RMNQGTESTR LFLLFLKERA AIEENYSKSL QKLLKSTSQL
IEYGTLRDAW YGVRGEAESL VRVHHELGQK IEKDIVAPFS KFKSEQKKVK KNFLYDAYKL
NKERKDMESS ITKTRAKYDD YSKQAETIAI TMETAKNTKT AAEVGKIQSK LQKIQRDASS
AEQDYRDSVN KLSMYQPTWE DKVSSNYHTL QLTEEERIDY IKVQLEKYVG AIKSTVPDTE
TTNRNLVNVI TQIDKLEDIH CFVRESRTGT EKPPPPQFIS FGGKSSSDYI QNKASYSAPL
TSSVSSNSLT SSYNSATTTP TPAPRSTPIN LSKKKQAKAL YDYVGSDATE LDFFAGDIIT
ILDEDESGWF RGELGDRIGL YPSNYCEPI
