ID   Y4701_DICDI             Reviewed;         437 AA.
AC   P0CC06; C7G029;
DT   15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Enolase superfamily member DDB_G0284701;
DE            EC=5.-.-.-;
GN   ORFNames=DDB_G0284701;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the mandelate racemase/muconate lactonizing
CC       enzyme family. {ECO:0000305}.
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DR   EMBL; AAFI02000070; EEU04090.1; -; Genomic_DNA.
DR   RefSeq; XP_002649142.1; XM_002649096.1.
DR   AlphaFoldDB; P0CC06; -.
DR   SMR; P0CC06; -.
DR   STRING; 44689.DDB0252813; -.
DR   PaxDb; P0CC06; -.
DR   PRIDE; P0CC06; -.
DR   EnsemblProtists; EEU04090; EEU04090; DDB_G0284701.
DR   GeneID; 8624736; -.
DR   KEGG; ddi:DDB_G0284701; -.
DR   dictyBase; DDB_G0284701; -.
DR   eggNOG; ENOG502S1E1; Eukaryota.
DR   HOGENOM; CLU_712634_0_0_1; -.
DR   InParanoid; P0CC06; -.
DR   OMA; IEMAIFD; -.
DR   PhylomeDB; P0CC06; -.
DR   PRO; PR:P0CC06; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.120; -; 1.
DR   Gene3D; 3.30.390.10; -; 1.
DR   InterPro; IPR036849; Enolase-like_C_sf.
DR   InterPro; IPR029017; Enolase-like_N.
DR   InterPro; IPR029065; Enolase_C-like.
DR   InterPro; IPR034593; Mandelate_racemase_DgoD-like.
DR   PANTHER; PTHR48080; PTHR48080; 1.
DR   Pfam; PF13378; MR_MLE_C; 1.
DR   SUPFAM; SSF51604; SSF51604; 1.
DR   SUPFAM; SSF54826; SSF54826; 1.
PE   3: Inferred from homology;
KW   Isomerase; Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..437
FT                   /note="Enolase superfamily member DDB_G0284701"
FT                   /id="PRO_0000389024"
FT   ACT_SITE        217
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        395
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         251
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         279
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         321
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   437 AA;  49750 MW;  63C557EDBF85551C CRC64;
     MTKMLKFLFK NKINVELSIK QYKLNLRNPF GTAHSVTTTR TNALIEIKVE DIRGFGECGL
     PPKKPLCYLA DYNDIETYFN SWIKEIDEKQ KQQQQQQEES YHYDAFNKIS QKEYFKELRK
     EMNGDYQQSV YQFLFECLDN CKENSKDYSY ASRCAIEMAL LDGWGKFLKQ PIYKLINIPE
     SESLKPFYYT ISMCPTMEEI MDSTDFGSKY TGFLKIKLDA DVEKGMNIID SVQKRLLNNN
     STRTISKISV DANSSWTPSV ARKYLEKLSP MADLISMVEQ PFPIETLKTV NKDQKIDIQH
     LNEWVSIKKE YQDKGLLIFA DESICTEKDL DGLVQLVHGV NIKLEKTGGI RPGLSTLLKA
     KELGLKTWIG SMVASSLNVS AAAHLLCSLS DFGGDLDGGL LIDDATQLFE NDAFQLLDNG
     LIKMNSNNYG VGVTLKK