ID   Y472_MYCTO              Reviewed;         234 AA.
AC   P9WMD8; L0T3U8; O53757; Q7D9R3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT0489;
GN   OrderedLocusNames=MT0489;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK44712.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK44712.1; ALT_INIT; Genomic_DNA.
DR   PIR; D70829; D70829.
DR   RefSeq; WP_003402330.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMD8; -.
DR   SMR; P9WMD8; -.
DR   EnsemblBacteria; AAK44712; AAK44712; MT0489.
DR   GeneID; 45424433; -.
DR   KEGG; mtc:MT0489; -.
DR   PATRIC; fig|83331.31.peg.519; -.
DR   HOGENOM; CLU_069356_11_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR045823; TetR_C_32.
DR   Pfam; PF19344; TetR_C_32; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..234
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT0489"
FT                   /id="PRO_0000427321"
FT   DOMAIN          24..83
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        46..65
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   234 AA;  26418 MW;  298B60EBAB6482D2 CRC64;
     MAERIPAVTV KTDGRKRRWH QHKVERRNEL VDGTIEAIRR HGRFLSMDEI AAEIGVSKTV
     LYRYFVDKND LTTAVMMRFT QTTLIPNMIA ALSADMDGFE LTREIIRVYV ETVAAQPEPY
     RFVMANSSAS KSKVIADSER IIARMLAVML RRRMQEAGMD TGGVEPWAYL IVGGVQLATH
     SWMSDPRMSS DELIDYLTML SWSALCGIVE AGGSLEKFRE QPHPSPIVPA WGQV