ID   Y474_STRAW              Reviewed;         283 AA.
AC   Q82QN1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase SAV_474/SAV474;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=SAV_474;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; BA000030; BAC68184.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q82QN1; -.
DR   SMR; Q82QN1; -.
DR   STRING; 227882.SAV_474; -.
DR   EnsemblBacteria; BAC68184; BAC68184; SAVERM_474.
DR   KEGG; sma:SAVERM_474; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_0_11; -.
DR   OMA; GSAASMW; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..283
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase SAV_474/SAV474"
FT                   /id="PRO_0000361264"
FT   REGION          258..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         121
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         150..151
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   283 AA;  30658 MW;  A7A7BD872C63FAAC CRC64;
     MTDEQERVQP SGVWATAVGV ARVRALETER ENALFRDPLA QAFATAGGLW PSSPPLPDDE
     AARRRRLTVS FSIVIRTKFL DDLLQQASAS GVRQVVLLGA GMDSRAFRMD WPEGTRLFEV
     DTAAPLDFKA SVLRQERADA RCERITVAVD LREDWPGALA AVGHDPAVPT VWIAEGLLIY
     LPEDAVELLL ARISAQSAAG SRMGLTLGSR GVIERFGADA APGSAASMWV SEMPDDPVGW
     LAGHGWEADS HTLRERAAAY GRPISTPPQR EERPGGLISA VRR