ID   Y4755_DICDI             Reviewed;         473 AA.
AC   Q54P71;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable acid phosphatase DDB_G0284755;
DE            EC=3.1.3.2;
GN   ORFNames=DDB_G0284755;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC         Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000071; EAL65030.2; -; Genomic_DNA.
DR   RefSeq; XP_638387.2; XM_633295.2.
DR   AlphaFoldDB; Q54P71; -.
DR   SMR; Q54P71; -.
DR   STRING; 44689.DDB0302470; -.
DR   PaxDb; Q54P71; -.
DR   EnsemblProtists; EAL65030; EAL65030; DDB_G0284755.
DR   GeneID; 8624756; -.
DR   KEGG; ddi:DDB_G0284755; -.
DR   dictyBase; DDB_G0284755; -.
DR   eggNOG; KOG3720; Eukaryota.
DR   HOGENOM; CLU_030431_5_0_1; -.
DR   InParanoid; Q54P71; -.
DR   OMA; PCHGSRE; -.
DR   PhylomeDB; Q54P71; -.
DR   Reactome; R-DDI-1483166; Synthesis of PA.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   PRO; PR:Q54P71; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; -; 1.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   Pfam; PF00328; His_Phos_2; 1.
DR   SUPFAM; SSF53254; SSF53254; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..473
FT                   /note="Probable acid phosphatase DDB_G0284755"
FT                   /id="PRO_0000369255"
FT   ACT_SITE        94
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        359
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   473 AA;  54859 MW;  AE73C64497CD293A CRC64;
     MIINFLLNSI VGTVKLDENP NINLKNNINN NDNNKENSIE INDYLQTLVK EEDFKNQHTD
     PNFKFLALRS TKVPIDEYNP ENYQLKFVQI ITRHGRRTPE SKRYPLTMWT CNSLDQLITN
     KDTSRPDCNM GQLTVLGIVD QINVGKAYRN LFINNLHFLD NKYNKDQIFI RSSNRERTIS
     SARSFMHGLY GGSFADDQEK SPNHSSFLIL DEKDENMYPR SSPKYNFLKG LLKKHKAVIE
     ENEKSNLKEF TEKIKNIFED SKFDTAFYVP SWRSYAGLVN SFDCFRNNGL PLPKGFTNDV
     IQRMYEESAK EFKSARLFPE MSILGIGRFV NDLTKQMYLK SVNDPSVKDL KLSLYSGHDT
     TLAALLVAYD MYEDNVHPVT SSALEYLLFQ DKNYKEPEVV TKSNEKELIN HQYVKVIFNH
     KPIHIGPCKD KEVDGMCPLS EFLKISQSII PTNYDEQSKI TDEEKNKYIQ EST