ID   Y4757_DICDI             Reviewed;         766 AA.
AC   Q54P70;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=OTU domain-containing protein DDB_G0284757;
DE            EC=3.1.2.-;
GN   ORFNames=DDB_G0284757;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
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DR   EMBL; AAFI02000071; EAL65031.2; -; Genomic_DNA.
DR   RefSeq; XP_638388.2; XM_633296.2.
DR   AlphaFoldDB; Q54P70; -.
DR   SMR; Q54P70; -.
DR   STRING; 44689.DDB0302471; -.
DR   MEROPS; C85.A07; -.
DR   PaxDb; Q54P70; -.
DR   EnsemblProtists; EAL65031; EAL65031; DDB_G0284757.
DR   GeneID; 8624757; -.
DR   KEGG; ddi:DDB_G0284757; -.
DR   dictyBase; DDB_G0284757; -.
DR   eggNOG; KOG2605; Eukaryota.
DR   HOGENOM; CLU_364651_0_0_1; -.
DR   InParanoid; Q54P70; -.
DR   OMA; RKTIVDW; -.
DR   PRO; PR:Q54P70; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR   GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF02338; OTU; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50802; OTU; 1.
PE   4: Predicted;
KW   Hydrolase; Protease; Reference proteome; Thiol protease.
FT   CHAIN           1..766
FT                   /note="OTU domain-containing protein DDB_G0284757"
FT                   /id="PRO_0000369254"
FT   DOMAIN          631..765
FT                   /note="OTU"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00139"
FT   REGION          129..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..566
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        639
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        642
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        758
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   766 AA;  88807 MW;  47F3A90F6693A85E CRC64;
     MSHSANFVNV QSPPSYIQLA QQQQQQQQQQ LQQQQQTQNP TSPTSFLAQQ QYSGNIPTTA
     SNQQPYQHIP QPYQPNISSI LQPLPIRYIY VNQLPLAQQQ QQLQQNQLQQ QPPNVIYQQQ
     PLIVQQQQQP NTVQQQQQQP PQTIQQQPNM AQPQPQQTQQ FTMEQTFQNI LNKIKDKFDK
     FTTNHVGQDN ITFNNAQLPI AKECNTILLK LQNNRNIHTS SLPFTLTPEV YKPPEFFTKV
     DIIQYHLSGL ASILVLMKLS QVDPSFAKQI NLMTVKSKFM IEMLAKIFQQ QLDNRNNNNN
     NNTMSMSITN STVLSSQKNN NPIIIYFNQQ FENIKQLKDY FETSDISSNG LVFFTQTLFS
     MLTGRGYFWY IGEEVTKQLK YKIFETIYDN LFRTVMKCTS ETKYKYNLGC FCYSYFKIIQ
     SDHQVTSARF VTQKPQIKDD LYKYLLHYLS LSNDQLSRAL SDVPISDSTI WLIYAKTCCL
     LNQEEKAQIW IQYFINEATD RVTAAAMIQL DEDIAHYHSK SWYVDIMKSI EEEKKKRIEE
     DDRLNKQRKQ QQQQQQSNSS SPHIVGGHVQ DQYSEIKTNL LLEGLVLKNM NHDASLISSN
     VLLNLHPLPQ SKEVQIAQQR LNERLELYML KNSKEIPGDG NCQMHALSDQ LYGDLSHSQE
     VRKTIVDWLR KNKDFQLPNG ATICQFVNTN NWDDYCNDMS KNGNWGDHLT LLAAAEHFGS
     KISIISSVES QSNFFIEIIP SKILNDKVLL LSHYAEFHYG SLCPLR