ID   Y4775_DICDI             Reviewed;         458 AA.
AC   Q86IV4; Q556C4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=PH domain-containing protein DDB_G0274775;
GN   ORFNames=DDB_G0274775;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
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DR   EMBL; AAFI02000012; EAL70280.1; -; Genomic_DNA.
DR   RefSeq; XP_643886.1; XM_638794.1.
DR   AlphaFoldDB; Q86IV4; -.
DR   SMR; Q86IV4; -.
DR   STRING; 44689.DDB0233285; -.
DR   PaxDb; Q86IV4; -.
DR   EnsemblProtists; EAL70280; EAL70280; DDB_G0274775.
DR   GeneID; 8619312; -.
DR   KEGG; ddi:DDB_G0274775; -.
DR   dictyBase; DDB_G0274775; phdI.
DR   eggNOG; KOG1738; Eukaryota.
DR   HOGENOM; CLU_566778_0_0_1; -.
DR   InParanoid; Q86IV4; -.
DR   OMA; FIGSWID; -.
DR   PRO; PR:Q86IV4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR   GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:dictyBase.
DR   GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR   GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR045188; Boi1/Boi2-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22902; PTHR22902; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..458
FT                   /note="PH domain-containing protein DDB_G0274775"
FT                   /id="PRO_0000368212"
FT   DOMAIN          15..112
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          111..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   458 AA;  51236 MW;  9B90A2F5228175DE CRC64;
     MSEPELKVSV SQLAPSDREG WLTKQGGSIR TWRRRWFVLK GKKLFYFKSK GDIEATGLIE
     LEQNSFVKEE KDKDKKKKYM FTVGTSKRVF YIFAETETDM KQWMESIKRN LDGEGGMKSG
     GNDIVSSPKI NSEPTPKVNQ NGSAPEKSSL SSPRSKISNA KSIIPFLREE ESKVLEFWQI
     WSESIPPQSD LQSGTAIEFH VATSIDMQKL TWRTAGPQNI FIQKMVDFFW NVGAPESEID
     RLNDVGAIIN PVKIGSWIDM SDKGGMDGGW YFPVDIPLKL AIEASDAGEP TRKLSEWAES
     NEVVNCYSIG RDMGAAPPRQ TETRFKLPGP DFIAQLNLAV DAFKTFEFPP IPSNALEILY
     QSSNTLEAGG LCLSVITSSE GFVRLGLLIP KPTRDVVGQL CEIGQANRER ISKFETALGG
     CGPAFVEFQY LQKGFGYTVY KEGFDIVFHY MVGEDQSE